MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways
miRNAs are small regulatory RNAs which govern gene expression post-transcriptionally by primarily binding to the 3'-UTR of mRNA target genes. miR-145 is a well-studied miRNA that has been implicated in controlling a range of biological processes. miR-145 is expressed in a variety of tissues and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2020-12-01
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| Series: | Vascular Biology |
| Subjects: | |
| Online Access: | https://vb.bioscientifica.com/view/journals/vb/aop/vb-20-0012/vb-20-0012.xml |
| Summary: | miRNAs are small regulatory RNAs which govern gene expression post-transcriptionally by primarily binding to the 3'-UTR of mRNA target genes. miR-145 is a well-studied miRNA that has been implicated in controlling a range of biological processes. miR-145 is expressed in a variety of tissues and cell types and acts as a tumor-suppressor by regulating target gene signaling pathways involved in different aspects of tumor growth and progression. There is also strong evidence that highlights the important functions of miR-145 in the cardiovascular system. Here, we review the mechanisms of miR-145 in tumorigenesis and cancer progression and compare and contrast with the roles of miR-145 in cardiovascular development and disease. We discuss the important targets of miR-145 in cancer and their possible link to the cardiovascular system. |
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| ISSN: | 2516-5658 2516-5658 |