Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system
Hybrid drug delivery systems (DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-05-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087616302719 |
| _version_ | 1831562662327091200 |
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| author | Sushilkumar A. Jadhav Valentina Brunella Dominique Scalarone Gloria Berlier |
| author_facet | Sushilkumar A. Jadhav Valentina Brunella Dominique Scalarone Gloria Berlier |
| author_sort | Sushilkumar A. Jadhav |
| collection | DOAJ |
| description | Hybrid drug delivery systems (DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature (LCST) of the copolymer. The results have revealed that due to the presence of small diameter (~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS. |
| first_indexed | 2024-12-17T10:42:14Z |
| format | Article |
| id | doaj.art-85f21776ca954ce09a3c7fc4d9f2deb5 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-17T10:42:14Z |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-85f21776ca954ce09a3c7fc4d9f2deb52022-12-21T21:52:14ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762017-05-0112327928410.1016/j.ajps.2017.02.002Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery systemSushilkumar A. JadhavValentina BrunellaDominique ScalaroneGloria BerlierHybrid drug delivery systems (DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature (LCST) of the copolymer. The results have revealed that due to the presence of small diameter (~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS.http://www.sciencedirect.com/science/article/pii/S1818087616302719Porous silica nanoparticlesThermoresponsive polymerDrug delivery systemIbuprofenDrug loadingDrug release profile |
| spellingShingle | Sushilkumar A. Jadhav Valentina Brunella Dominique Scalarone Gloria Berlier Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system Asian Journal of Pharmaceutical Sciences Porous silica nanoparticles Thermoresponsive polymer Drug delivery system Ibuprofen Drug loading Drug release profile |
| title | Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system |
| title_full | Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system |
| title_fullStr | Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system |
| title_full_unstemmed | Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system |
| title_short | Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system |
| title_sort | poly nipam co mps grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system |
| topic | Porous silica nanoparticles Thermoresponsive polymer Drug delivery system Ibuprofen Drug loading Drug release profile |
| url | http://www.sciencedirect.com/science/article/pii/S1818087616302719 |
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