| Summary: | The attribution of <sup>1</sup>H and <sup>13</sup>C NMR signals of a library of 5-, 6- and 7-substituted 2,2-dimethylchroman-4-one derivatives is reported. Substituent effects were interpreted in terms of the Hammett equation, showing a good correlation for carbons <i>para</i>- to the substituent group, not for the <i>meta</i>- ones. Similarly, the Lynch correlation shows the additivity of the substituent chemical shifts in the case of both H and C nuclei, again with the exception of the carbons in the <i>meta</i>- position. Density Functional Theory (DFT)-predicted <sup>1</sup>H and <sup>13</sup>C chemical shifts correspond closely with experimentally observed values, with some exceptions for C NMR data; however, the correlation is valid only for the aromatic moiety and cannot be extended to the heterocyclic ring of the chroman-4-one scaffold.
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