The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
Objective: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. Materials and methods: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were e...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455921002576 |
| _version_ | 1818835563869896704 |
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| author | Ismail Biyik Uzeyir Kalkan Sercan Simsek |
| author_facet | Ismail Biyik Uzeyir Kalkan Sercan Simsek |
| author_sort | Ismail Biyik |
| collection | DOAJ |
| description | Objective: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. Materials and methods: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were examined. T-cadherin, E-cadherin, ER-α and PR-α staining levels of DIE, endometrioma tissues and endometrial tissues were compared immunohistochemically. H-score was calculated to compare the expression of T-cadherin, E-cadherin, ER-α, PR-α in IHC staining based on the percentage of cells stained at each intensity level. Results: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue and the highest in endometrial tissue (p < 0.0001, <0.0001, <0.0001 and < 0.0001, respectively). In correlation analysis, a positive correlation was found between T-cadherin, E-cadherin, PR and ER H-score (p < 0.0001 for each). No correlation was found between age, body mass index (BMI), visual analog scale (VAS) score, CA125, endometrioma size and the severity of dysmenorrhea, dyspareunia and dystonia (p > 0.05). Conclusion: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue, the highest in endometrium tissue. The finding of lower expression of PR-α in endometriotic nodule in our study may be related to decrease in progesterone effect which could not inhibit the decrease in the expression of T-cadherin and E-cadherin, thus the invasiveness of DIE tissue. These findings suggest that DIE tissue and ovarian endometrioma tissues have a different biology. |
| first_indexed | 2024-12-19T02:52:43Z |
| format | Article |
| id | doaj.art-85f37972174b424da55c22c05590c1b1 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-19T02:52:43Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-85f37972174b424da55c22c05590c1b12022-12-21T20:38:31ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592021-11-0160610591065The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissueIsmail Biyik0Uzeyir Kalkan1Sercan Simsek2Kutahya Health Sciences University, School of Medicine, Department of Obstetrics and Gynaecology, Kutahya, Turkey; Corresponding author. Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi Yerleşkesi, Tavşanlı Yolu 10. km, Kütahya, Turkey. Fax: + 90 274 265 22 85.Koç University Hospital, Department of Obstetrics and Gynecology, Istanbul, TurkeyKutahya Evliya Celebi Education and Research Hospital, Department of Medical Pathology, Kutahya, TurkeyObjective: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. Materials and methods: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were examined. T-cadherin, E-cadherin, ER-α and PR-α staining levels of DIE, endometrioma tissues and endometrial tissues were compared immunohistochemically. H-score was calculated to compare the expression of T-cadherin, E-cadherin, ER-α, PR-α in IHC staining based on the percentage of cells stained at each intensity level. Results: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue and the highest in endometrial tissue (p < 0.0001, <0.0001, <0.0001 and < 0.0001, respectively). In correlation analysis, a positive correlation was found between T-cadherin, E-cadherin, PR and ER H-score (p < 0.0001 for each). No correlation was found between age, body mass index (BMI), visual analog scale (VAS) score, CA125, endometrioma size and the severity of dysmenorrhea, dyspareunia and dystonia (p > 0.05). Conclusion: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue, the highest in endometrium tissue. The finding of lower expression of PR-α in endometriotic nodule in our study may be related to decrease in progesterone effect which could not inhibit the decrease in the expression of T-cadherin and E-cadherin, thus the invasiveness of DIE tissue. These findings suggest that DIE tissue and ovarian endometrioma tissues have a different biology.http://www.sciencedirect.com/science/article/pii/S1028455921002576T-cadherinE-cadherinProgesterone receptorOestrogen receptorEndometriosis |
| spellingShingle | Ismail Biyik Uzeyir Kalkan Sercan Simsek The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue Taiwanese Journal of Obstetrics & Gynecology T-cadherin E-cadherin Progesterone receptor Oestrogen receptor Endometriosis |
| title | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue |
| title_full | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue |
| title_fullStr | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue |
| title_full_unstemmed | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue |
| title_short | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue |
| title_sort | deep infiltrating endometriosis tissue has lower t cadherin e cadherin progesterone receptor and oestrogen receptor than endometrioma tissue |
| topic | T-cadherin E-cadherin Progesterone receptor Oestrogen receptor Endometriosis |
| url | http://www.sciencedirect.com/science/article/pii/S1028455921002576 |
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