Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency
Primary ovarian insufficiency (POI) is an essential cause of young female fertility loss. At present, there are many treatments for primary ovarian insufficiency, but due to the complexity of the pathogenesis of primary ovarian insufficiency, the efficacy still could not be satisfactory. Stem cell t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1090997/full |
| _version_ | 1797924509168173056 |
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| author | Zixiang Geng Zixiang Geng Hailing Guo Hailing Guo Yifei Li Ying Liu Yongfang Zhao Yongfang Zhao |
| author_facet | Zixiang Geng Zixiang Geng Hailing Guo Hailing Guo Yifei Li Ying Liu Yongfang Zhao Yongfang Zhao |
| author_sort | Zixiang Geng |
| collection | DOAJ |
| description | Primary ovarian insufficiency (POI) is an essential cause of young female fertility loss. At present, there are many treatments for primary ovarian insufficiency, but due to the complexity of the pathogenesis of primary ovarian insufficiency, the efficacy still could not be satisfactory. Stem cell transplantation is a feasible intervention protocol for primary ovarian insufficiency. However, its wide application in the clinic is limited by some defects such as tumorigenic and controversial ethical issues. Stem cell-derived extracellular vesicles (EVs) represent an important mode of intercellular communication attracting increasing interest. It is well documented that stem cell-derived extracellular vesicles for primary ovarian insufficiency with exciting therapeutic effects. Studies have found that stem cell-derived extracellular vesicles could improve ovarian reserve, increase the growth of follicles, reduce follicle atresia, and restore hormone levels of FSH and E2. Its mechanisms include inhibiting ovarian granulosa cells (GCs) apoptosis, reactive oxygen species, and inflammatory response and promoting granulosa cells proliferation and angiogenesis. Thus, stem cell-derived extracellular vesicles are a promising and potential method for primary ovarian insufficiency patients. However, stem cell-derived extracellular vesicles are still a long way from clinical translation. This review will provide an overview of the role and the mechanisms of stem cell-derived extracellular vesicles in primary ovarian insufficiency, and further elaborate on the current challenges. It may suggest new directions for future research. |
| first_indexed | 2024-04-10T15:02:09Z |
| format | Article |
| id | doaj.art-85f3e58f3189448cb029f0afa953a38a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T15:02:09Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-85f3e58f3189448cb029f0afa953a38a2023-02-15T10:35:41ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-02-011110.3389/fcell.2023.10909971090997Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiencyZixiang Geng0Zixiang Geng1Hailing Guo2Hailing Guo3Yifei Li4Ying Liu5Yongfang Zhao6Yongfang Zhao7Shi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Traumatology and Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Traumatology and Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Songjiang District Central Hospital, Shanghai, ChinaShi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Traumatology and Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaPrimary ovarian insufficiency (POI) is an essential cause of young female fertility loss. At present, there are many treatments for primary ovarian insufficiency, but due to the complexity of the pathogenesis of primary ovarian insufficiency, the efficacy still could not be satisfactory. Stem cell transplantation is a feasible intervention protocol for primary ovarian insufficiency. However, its wide application in the clinic is limited by some defects such as tumorigenic and controversial ethical issues. Stem cell-derived extracellular vesicles (EVs) represent an important mode of intercellular communication attracting increasing interest. It is well documented that stem cell-derived extracellular vesicles for primary ovarian insufficiency with exciting therapeutic effects. Studies have found that stem cell-derived extracellular vesicles could improve ovarian reserve, increase the growth of follicles, reduce follicle atresia, and restore hormone levels of FSH and E2. Its mechanisms include inhibiting ovarian granulosa cells (GCs) apoptosis, reactive oxygen species, and inflammatory response and promoting granulosa cells proliferation and angiogenesis. Thus, stem cell-derived extracellular vesicles are a promising and potential method for primary ovarian insufficiency patients. However, stem cell-derived extracellular vesicles are still a long way from clinical translation. This review will provide an overview of the role and the mechanisms of stem cell-derived extracellular vesicles in primary ovarian insufficiency, and further elaborate on the current challenges. It may suggest new directions for future research.https://www.frontiersin.org/articles/10.3389/fcell.2023.1090997/fullprimary ovarian insufficiencypremature ovarian failurestem cellsextracellular vesiclesexosomes |
| spellingShingle | Zixiang Geng Zixiang Geng Hailing Guo Hailing Guo Yifei Li Ying Liu Yongfang Zhao Yongfang Zhao Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency Frontiers in Cell and Developmental Biology primary ovarian insufficiency premature ovarian failure stem cells extracellular vesicles exosomes |
| title | Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency |
| title_full | Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency |
| title_fullStr | Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency |
| title_full_unstemmed | Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency |
| title_short | Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency |
| title_sort | stem cell derived extracellular vesicles a novel and potential remedy for primary ovarian insufficiency |
| topic | primary ovarian insufficiency premature ovarian failure stem cells extracellular vesicles exosomes |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1090997/full |
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