Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients
Purpose. Emergence of carbapenem-resistant Acinetobacter baumannii (CRAB) and their prolonged presence in burn units increases the risk of acquisition of CRAB. Methods. From November 2012 to September 2013, 1474 burn patients were screened for CRAB isolates through testing susceptibility to imipene...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/27077 |
| _version_ | 1797716658469470208 |
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| author | Habibeh Adibhesami Masoumeh Douraghi Hojjat Zeraati Fariba Bazmi Mohammad Rahbar Mohammad Reza Pourmand Mahboobeh Satarzadeh Tabrizi Amir Aliramezani Sedigheh Ghourchian |
| author_facet | Habibeh Adibhesami Masoumeh Douraghi Hojjat Zeraati Fariba Bazmi Mohammad Rahbar Mohammad Reza Pourmand Mahboobeh Satarzadeh Tabrizi Amir Aliramezani Sedigheh Ghourchian |
| author_sort | Habibeh Adibhesami |
| collection | DOAJ |
| description | Purpose. Emergence of carbapenem-resistant Acinetobacter baumannii (CRAB) and their prolonged presence in burn units increases the risk of acquisition of CRAB.
Methods. From November 2012 to September 2013, 1474 burn patients were screened for CRAB isolates through testing susceptibility to imipenem and its comparators meropenem, and doripenem. Furthermore, the in vitro activity of other antibiotics against CRAB was investigated. Results. Three patients were infected with carbapenem-susceptible A. baumannii (CSAB) and 168 were infected with CRAB. Approximately one-fifth (n=32) of CRAB isolates were obtained from patients hospitalized in Burn Intensive Care Unit (BICU). Most of CRABs were isolated from wound. The mean length of stay (LOS) in hospital prior to A. baumannii isolation was significantly higher for CRAB compared to CSAB cases (P=0.04). Amongst the independent variables, percentage of total burn surface area (TBSA) significantly increased the mortality rate using multivariate logistic regression (P=0.001, OR= 16.5; 95% CI: 4.72-57.7). The majority of tested isolates were resistant to imipenem (94.8%), and to its comparators, doripenem (97.7%), and meropenem (97.7%). The susceptibility of CRAB isolates was less than 10% to all tested antibiotics except for colistin (100%), doxycycline (61.9%), gentamicin (18.5%), and tigecycline (11.9%).
Conclusion. Resistance to carbapenem reduces the number of effective antibiotics. The coordinated and intensive efforts of healthcare personnel are required to meet the challenge of dissemination of CRAB. |
| first_indexed | 2024-03-12T08:24:45Z |
| format | Article |
| id | doaj.art-85f6b55784664147a2143960c2c74275 |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T08:24:45Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-85f6b55784664147a2143960c2c742752023-09-02T18:11:46ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262016-08-0119310.18433/J3QK6MCarbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn PatientsHabibeh Adibhesami0Masoumeh Douraghi1Hojjat Zeraati2Fariba Bazmi3Mohammad Rahbar4Mohammad Reza Pourmand5Mahboobeh Satarzadeh Tabrizi6Amir Aliramezani7Sedigheh Ghourchian8Division of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDivision of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences; and Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, IranMicrobiology Laboratory, Motahari Burn Center, Iran University of Medical Sciences, Tehran, IranDepartment of Microbiology, Reference Health Laboratories, Ministry of Health, Tehran, IranDivision of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranMicrobiology Laboratory, Motahari Burn Center, Iran University of Medical Sciences, Tehran, IranDivision of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDivision of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranPurpose. Emergence of carbapenem-resistant Acinetobacter baumannii (CRAB) and their prolonged presence in burn units increases the risk of acquisition of CRAB. Methods. From November 2012 to September 2013, 1474 burn patients were screened for CRAB isolates through testing susceptibility to imipenem and its comparators meropenem, and doripenem. Furthermore, the in vitro activity of other antibiotics against CRAB was investigated. Results. Three patients were infected with carbapenem-susceptible A. baumannii (CSAB) and 168 were infected with CRAB. Approximately one-fifth (n=32) of CRAB isolates were obtained from patients hospitalized in Burn Intensive Care Unit (BICU). Most of CRABs were isolated from wound. The mean length of stay (LOS) in hospital prior to A. baumannii isolation was significantly higher for CRAB compared to CSAB cases (P=0.04). Amongst the independent variables, percentage of total burn surface area (TBSA) significantly increased the mortality rate using multivariate logistic regression (P=0.001, OR= 16.5; 95% CI: 4.72-57.7). The majority of tested isolates were resistant to imipenem (94.8%), and to its comparators, doripenem (97.7%), and meropenem (97.7%). The susceptibility of CRAB isolates was less than 10% to all tested antibiotics except for colistin (100%), doxycycline (61.9%), gentamicin (18.5%), and tigecycline (11.9%). Conclusion. Resistance to carbapenem reduces the number of effective antibiotics. The coordinated and intensive efforts of healthcare personnel are required to meet the challenge of dissemination of CRAB.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/27077 |
| spellingShingle | Habibeh Adibhesami Masoumeh Douraghi Hojjat Zeraati Fariba Bazmi Mohammad Rahbar Mohammad Reza Pourmand Mahboobeh Satarzadeh Tabrizi Amir Aliramezani Sedigheh Ghourchian Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients Journal of Pharmacy & Pharmaceutical Sciences |
| title | Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients |
| title_full | Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients |
| title_fullStr | Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients |
| title_full_unstemmed | Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients |
| title_short | Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients |
| title_sort | carbapenem resistant acinetobacter baumannii crab recovered from burn patients |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/27077 |
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