Genotype directed therapy in murine mismatch repair deficient tumors.

Genotype directed therapy in murine mismatch repair deficient tumors.

The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2(-/-) initiated intestinal tumors. NVP-BEZ235 is a dual PI3K/mTOR inhibitor toxic to many cancer cell line...

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Bibliographic Details
Main Authors: Melanie H Kucherlapati, Shadi Esfahani, Peiman Habibollahi, Junning Wang, Eric R Still, Roderick T Bronson, Umar Mahmood, Raju S Kucherlapati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720855?pdf=render

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