Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop
Currently it is estimated that about 1 billion people globally have non-alcoholic fatty liver disease (NAFLD), a condition in which liver fat exceeds 5 % of liver weight in the absence of significant alcohol intake. Due to the central role of the liver in metabolism, the prevalence of NAFLD is incre...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2017-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679017000131/type/journal_article |
| _version_ | 1811155926046998528 |
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| author | Harry P. F. Peters Patrick Schrauwen Petra Verhoef Christopher D. Byrne David J. Mela Andreas F. H. Pfeiffer Ulf Risérus Frits R. Rosendaal Vera Schrauwen-Hinderling |
| author_facet | Harry P. F. Peters Patrick Schrauwen Petra Verhoef Christopher D. Byrne David J. Mela Andreas F. H. Pfeiffer Ulf Risérus Frits R. Rosendaal Vera Schrauwen-Hinderling |
| author_sort | Harry P. F. Peters |
| collection | DOAJ |
| description | Currently it is estimated that about 1 billion people globally have non-alcoholic fatty liver disease (NAFLD), a condition in which liver fat exceeds 5 % of liver weight in the absence of significant alcohol intake. Due to the central role of the liver in metabolism, the prevalence of NAFLD is increasing in parallel with the prevalence of obesity, insulin resistance and other risk factors of metabolic diseases. However, the contribution of liver fat to the risk of type 2 diabetes mellitus and CVD, relative to other ectopic fat depots and to other risk markers, is unclear. Various studies have suggested that the accumulation of liver fat can be reduced or prevented via dietary changes. However, the amount of liver fat reduction that would be physiologically relevant, and the timeframes and dose–effect relationships for achieving this through different diet-based approaches, are unclear. Also, it is still uncertain whether the changes in liver fat per se or the associated metabolic changes are relevant. Furthermore, the methods available to measure liver fat, or even individual fatty acids, differ in sensitivity and reliability. The present report summarises key messages of presentations from different experts and related discussions from a workshop intended to capture current views and research gaps relating to the points above. |
| first_indexed | 2024-04-10T04:43:02Z |
| format | Article |
| id | doaj.art-85f7cb6a18ee4d9c9eb0ab1717ff7e5c |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:02Z |
| publishDate | 2017-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-85f7cb6a18ee4d9c9eb0ab1717ff7e5c2023-03-09T12:38:57ZengCambridge University PressJournal of Nutritional Science2048-67902017-01-01610.1017/jns.2017.13Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshopHarry P. F. Peters0Patrick Schrauwen1Petra Verhoef2Christopher D. Byrne3David J. Mela4Andreas F. H. Pfeiffer5Ulf Risérus6Frits R. Rosendaal7Vera Schrauwen-Hinderling8Unilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen, The NetherlandsDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The NetherlandsUnilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen, The NetherlandsNutrition and Metabolism, Faculty of Medicine, University of Southampton & Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton, UKUnilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen, The NetherlandsDepartment of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam and German Center for Diabetes Research, DZD, Neuherberg, GermanyDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Unit, Uppsala University, SwedenDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands Department of Radiology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The NetherlandsCurrently it is estimated that about 1 billion people globally have non-alcoholic fatty liver disease (NAFLD), a condition in which liver fat exceeds 5 % of liver weight in the absence of significant alcohol intake. Due to the central role of the liver in metabolism, the prevalence of NAFLD is increasing in parallel with the prevalence of obesity, insulin resistance and other risk factors of metabolic diseases. However, the contribution of liver fat to the risk of type 2 diabetes mellitus and CVD, relative to other ectopic fat depots and to other risk markers, is unclear. Various studies have suggested that the accumulation of liver fat can be reduced or prevented via dietary changes. However, the amount of liver fat reduction that would be physiologically relevant, and the timeframes and dose–effect relationships for achieving this through different diet-based approaches, are unclear. Also, it is still uncertain whether the changes in liver fat per se or the associated metabolic changes are relevant. Furthermore, the methods available to measure liver fat, or even individual fatty acids, differ in sensitivity and reliability. The present report summarises key messages of presentations from different experts and related discussions from a workshop intended to capture current views and research gaps relating to the points above.https://www.cambridge.org/core/product/identifier/S2048679017000131/type/journal_articleLiver fatDietType 2 diabetesCardiovascular disease |
| spellingShingle | Harry P. F. Peters Patrick Schrauwen Petra Verhoef Christopher D. Byrne David J. Mela Andreas F. H. Pfeiffer Ulf Risérus Frits R. Rosendaal Vera Schrauwen-Hinderling Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop Journal of Nutritional Science Liver fat Diet Type 2 diabetes Cardiovascular disease |
| title | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop |
| title_full | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop |
| title_fullStr | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop |
| title_full_unstemmed | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop |
| title_short | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop |
| title_sort | liver fat a relevant target for dietary intervention summary of a unilever workshop |
| topic | Liver fat Diet Type 2 diabetes Cardiovascular disease |
| url | https://www.cambridge.org/core/product/identifier/S2048679017000131/type/journal_article |
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