α<sub>v</sub>β<sub>3</sub>-Specific Gold Nanoparticles for Fluorescence Imaging of Tumor Angiogenesis

α<sub>v</sub>β<sub>3</sub>-Specific Gold Nanoparticles for Fluorescence Imaging of Tumor Angiogenesis

This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs w...

Full description

Bibliographic Details
Main Authors:	Marc Pretze, Valeska von Kiedrowski, Roswitha Runge, Robert Freudenberg, René Hübner, Güllü Davarci, Ralf Schirrmacher, Carmen Wängler, Björn Wängler
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Nanomaterials
Subjects:	gold nanoparticle optical imaging radiosensitizer tumor angiogenesis RGD peptide
Online Access:	https://www.mdpi.com/2079-4991/11/1/138

Similar Items

Radiosynthesis of Stable <sup>198</sup>Au-Nanoparticles by Neutron Activation of α<sub>v</sub>β<sub>3</sub>-Specific AuNPs for Therapy of Tumor Angiogenesis
by: Güllü Davarci, et al.
Published: (2023-11-01)

Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFA<i>lin</i>-Modified Peptidic Radioligands Targeting Both Integrin α<sub>v</sub>β<sub>3</sub> and the MC1 Receptor—Suitable for the Specific Visualization of Melanomas?
by: Xia Cheng, et al.
Published: (2021-06-01)

Hybrid Multimodal Imaging Synthons for Chemoselective and Efficient Biomolecule Modification with Chelator and Near-Infrared Fluorescent Cyanine Dye
by: Ralph Hübner, et al.
Published: (2020-09-01)

Molecular Imaging of Angiogenesis in Oncology: Current Preclinical and Clinical Status
by: Alexandru Florea, et al.
Published: (2021-05-01)

TiO<sub>2</sub>/Au/TiO<sub>2</sub> Plasmonic Photocatalysts: The Influence of Titania Matrix and Gold Properties
by: Kenta Yoshiiri, et al.
Published: (2022-06-01)

Efficacy of a Selective Binder of α<sub>V</sub>β<sub>3</sub> Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models
by: Andrea Sartori, et al.
Published: (2019-04-01)

First-in-Human Study of [<sup>68</sup>Ga]Ga-NODAGA-E[c(RGDyK)]<sub>2</sub> PET for Integrin α<sub>v</sub>β<sub>3</sub> Imaging in Patients with Breast Cancer and Neuroendocrine Neoplasms: Safety, Dosimetry and Tumor Imaging Ability
by: Malene Martini Clausen, et al.
Published: (2022-03-01)

On the Primary Water Radicals’ Production in the Presence of Gold Nanoparticles: Electron Pulse Radiolysis Study
by: Viacheslav Shcherbakov, et al.
Published: (2020-12-01)

Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease
by: Matthieu Dietz, et al.
Published: (2021-08-01)

PESIN Conjugates for Multimodal Imaging: Can Multimerization Compensate Charge Influences on Cell Binding Properties? A Case Study
by: Ralph Hübner, et al.
Published: (2021-06-01)

Toward Optimized <sup>89</sup>Zr-Immuno-PET: Side-by-Side Comparison of [<sup>89</sup>Zr]Zr-DFO-, [<sup>89</sup>Zr]Zr-3,4,3-(LI-1,2-HOPO)- and [<sup>89</sup>Zr]Zr-DFO*-Cetuximab for Tumor Imaging: Which Chelator Is the Most Suitable?
by: Helen Damerow, et al.
Published: (2022-10-01)

Angiogenesis imaging study using interim [18F] RGD-K5 PET/CT in patients with lymphoma undergoing chemotherapy: preliminary evidence
by: David Tonnelet, et al.
Published: (2021-04-01)

Effects of Gold Nanoparticles on Angiogenesis in A Chick Chorioallantoic Membrane Model
by: Samet CIRIK, et al.
Published: (2020-10-01)

PET Diagnostic Molecules Utilizing Multimeric Cyclic RGD Peptide Analogs for Imaging Integrin α<sub>v</sub>β<sub>3</sub> Receptors
by: Christos Liolios, et al.
Published: (2021-03-01)

Palmitic Acid-Conjugated Radiopharmaceutical for Integrin α<sub>v</sub>β<sub>3</sub>-Targeted Radionuclide Therapy
by: Guangjie Yang, et al.
Published: (2022-06-01)

Dose Rate Effects on the Selective Radiosensitization of Prostate Cells by GRPR-Targeted Gold Nanoparticles
by: Ana Marques, et al.
Published: (2022-05-01)

Expanding the Range: AuCu Metal Aerogels from H<sub>2</sub>O and EtOH
by: Maximilian Georgi, et al.
Published: (2022-04-01)

Functionalization of Fe<sub>3</sub>O<sub>4</sub>/SiO<sub>2</sub> with N-(2-Aminoethyl)-3-aminopropyl for Sorption of [AuCl<sub>4</sub>]<sup>-</sup>
by: Nuryono Nuryono, et al.
Published: (2016-08-01)

Ultrathin gold nanowires to enhance radiation therapy
by: Lin Bai, et al.
Published: (2020-09-01)

Comparison of Linear vs. Cyclic RGD Pentapeptide Interactions with Integrin α<sub>v</sub>β<sub>3</sub> by Molecular Dynamics Simulations
by: Na Li, et al.
Published: (2021-07-01)

Catalytic Oxidation of Benzyl Alcohol to Benzaldehyde on Au<sub>8</sub> and Au<sub>6</sub>Pd<sub>2</sub> Clusters: A DFT Study on the Reaction Mechanism
by: Jitlada Kodchasee, et al.
Published: (2021-06-01)

Aggregation of Gold Nanoparticles in Presence of the Thermoresponsive Cationic Diblock Copolymer PNIPAAM<sub>48</sub>-b-PAMPTMA<sub>6</sub>
by: David Herrera Robalino, et al.
Published: (2021-11-01)

Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
by: Darweesh RS, et al.
Published: (2019-09-01)

A Label-Free Colorimetric Assay Based on Gold Nanoparticles for the Detection of H<sub>2</sub>O<sub>2</sub> and Glucose
by: Cong Zheng, et al.
Published: (2022-03-01)

The Au<sub>12</sub> Gold Cluster: Preference for a Non-Planar Structure
by: Pham Vu Nhat, et al.
Published: (2022-08-01)

Enhanced Radiosensitization for Cancer Treatment with Gold Nanoparticles through Sonoporation
by: Shao-Lun Lu, et al.
Published: (2020-11-01)

Gold Nanoparticle-Loaded Porous Poly(ethylene glycol) Nanosheets for Electrochemical Detection of H<sub>2</sub>O<sub>2</sub>
by: Zhiyong Zhao, et al.
Published: (2023-12-01)

Gold(III) Complexation in the Presence of the Macropolyhedral Hydridoborate Cluster [B<sub>20</sub>H<sub>18</sub>]<sup>2−</sup>
by: Varvara V. Avdeeva, et al.
Published: (2022-07-01)

Comparative Evaluation of Radiochemical and Biological Properties of <sup>131</sup>I- and [<sup>99m</sup>Tc]Tc(CO)<sub>3</sub>-Labeled RGD Analogues Planned to Interact with the α<sub>v</sub>β<sub>3</sub> Integrin Expressed in Glioblastoma
by: Danielle V. Sobral, et al.
Published: (2022-01-01)

Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis
by: Didier J. Colin, et al.
Published: (2016-10-01)

Albumin-Modified Gold Nanoparticles as Novel Radiosensitizers for Enhancing Lung Cancer Radiotherapy
by: Chen Y, et al.
Published: (2023-04-01)

Differential Sensing of Antibiotics Using Metal Ions and Gold Nanoclusters Based on TMB–H<sub>2</sub>O<sub>2</sub> System
by: Suqin Liu, et al.
Published: (2022-06-01)

Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo
by: Roma-Rodrigues C, et al.
Published: (2016-06-01)

Noninvasive Evaluation of Angiogenesis and Therapeutic Response after Hindlimb Ischemia with an Integrin-Targeted Tracer by PET
by: Zhongchan Sun, et al.
Published: (2022-12-01)

Synthesis and characterization of core-shell Fe<sub>3</sub>O<sub>4</sub>-gold-chitosan nanostructure
by: Salehizadeh Hossein, et al.
Published: (2012-01-01)

The Role of Gold Nanorods in the Response of Prostate Cancer and Normal Prostate Cells to Ionizing Radiation—In Vitro Model
by: Marika Musielak, et al.
Published: (2020-12-01)

Bovine Adenovirus-3 Tropism for Bovine Leukocyte Sub-Populations
by: Sugandhika Khosa, et al.
Published: (2020-12-01)

H<sub>2</sub>O<sub>2</sub>/Glucose Sensor Based on a Pyrroloquinoline Skeleton-Containing Molecule Modified Gold Cavity Array Electrode
by: Kaiyue Wang, et al.
Published: (2022-05-01)

Study on the Purity of Gold Leaf in a SO<sub>2</sub> Atmosphere at Ambient Temperature
by: Houyi Huang, et al.
Published: (2021-05-01)

Scissor-like Au<sub>4</sub>Cu<sub>2</sub> Cluster with Phosphorescent Mechanochromism and Thermochromism
by: Xue-Meng Wu, et al.
Published: (2023-04-01)