The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy

The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy

Sphingosine kinase 1 (SPHK1) is a crucial molecule that catalyzes sphingosine to synthesize sphingosine-1-phosphate (S1P), facilitating cell survival signaling. Pyroptosis is a perplexing inflammatory mode of cell death primarily triggered by caspase-1, evoked by the NLRP3 inflammasome. Sphingosine...

Full description

Bibliographic Details
Main Authors: Xianwang Wang, Yue Yang, Wen-Qi Cai, Yingying Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
spingosine kinase 1
pyroptosis
calcium and integrin-binding protein 1
cancer
sphingosine-1-phosphate
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.574990/full

Similar Items

Similar Items