Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients
Heart failure is the leading cause of morbidity and mortality worldwide, with ischemic heart disease being one of the most important etiologic factors. Heart failure develops due to ventricular remodeling, which leads to increases in left ventricular end-systolic and end-diastolic volumes. In thi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2021-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/393304 |
| _version_ | 1827282123992596480 |
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| author | Ozren Vinter Krešimir Kordić Iva Klobučar Ivo Darko Gabrić Marko Boban Matias Trbušić |
| author_facet | Ozren Vinter Krešimir Kordić Iva Klobučar Ivo Darko Gabrić Marko Boban Matias Trbušić |
| author_sort | Ozren Vinter |
| collection | DOAJ |
| description | Heart failure is the leading cause of morbidity and mortality worldwide, with
ischemic heart disease being one of the most important etiologic factors. Heart failure develops due to
ventricular remodeling, which leads to increases in left ventricular end-systolic and end-diastolic volumes.
In this prospective observational study, we included 101 patients with first episode of ST-segment
elevation myocardial infarction in whom percutaneous coronary intervention was conducted
within 12 h and Thrombolysis in Myocardial Infarction III flow was achieved. The aim was to determine
which clinical and biochemical parameters can help predict pathologic ventricular remodeling
1 year after myocardial infarction. We created a nomogram based on routinely used blood tests and
vital parameters which showed highest correlation with pathologic ventricular remodeling. The nomogram
included NTproBNP value 12 h after reperfusion, aspartate transaminase value 12 h after reperfusion,
systolic blood pressure value on admission, and culprit coronary artery. We performed ROC
analysis which yielded great predictive value of the nomogram. The area under curve was 0.907 (95%
CI 0.842-0.973). The nomogram value of -3.54 had 91.4% sensitivity and 74.0% specificity. We believe
that this nomogram, once validated, could offer a widely available, low-cost option that would
help identify patients at risk of developing pathologic left ventricular remodeling and achieve this at a
very early stage of myocardial infarction (12 h after reperfusion has been achieved). |
| first_indexed | 2024-04-24T09:12:49Z |
| format | Article |
| id | doaj.art-85f9cceefac0473bba2a433b9ac29b6b |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:12:49Z |
| publishDate | 2021-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-85f9cceefac0473bba2a433b9ac29b6b2024-04-15T17:31:41ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512021-01-0160.3.37938810.20471/acc.2021.60.03.07Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI PatientsOzren Vinter0Krešimir Kordić1Iva Klobučar2Ivo Darko Gabrić3Marko Boban4Matias Trbušić5Sestre milosrdnice University Hospital Centre, Zagreb, CroatiaSestre milosrdnice University Hospital Centre, Zagreb, CroatiaSestre milosrdnice University Hospital Centre, Zagreb, CroatiaSestre milosrdnice University Hospital Centre, Zagreb, CroatiaSestre milosrdnice University Hospital Centre, Zagreb, CroatiaSestre milosrdnice University Hospital Centre, Zagreb, CroatiaHeart failure is the leading cause of morbidity and mortality worldwide, with ischemic heart disease being one of the most important etiologic factors. Heart failure develops due to ventricular remodeling, which leads to increases in left ventricular end-systolic and end-diastolic volumes. In this prospective observational study, we included 101 patients with first episode of ST-segment elevation myocardial infarction in whom percutaneous coronary intervention was conducted within 12 h and Thrombolysis in Myocardial Infarction III flow was achieved. The aim was to determine which clinical and biochemical parameters can help predict pathologic ventricular remodeling 1 year after myocardial infarction. We created a nomogram based on routinely used blood tests and vital parameters which showed highest correlation with pathologic ventricular remodeling. The nomogram included NTproBNP value 12 h after reperfusion, aspartate transaminase value 12 h after reperfusion, systolic blood pressure value on admission, and culprit coronary artery. We performed ROC analysis which yielded great predictive value of the nomogram. The area under curve was 0.907 (95% CI 0.842-0.973). The nomogram value of -3.54 had 91.4% sensitivity and 74.0% specificity. We believe that this nomogram, once validated, could offer a widely available, low-cost option that would help identify patients at risk of developing pathologic left ventricular remodeling and achieve this at a very early stage of myocardial infarction (12 h after reperfusion has been achieved).https://hrcak.srce.hr/file/393304Acute myocardial infarctionLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volume |
| spellingShingle | Ozren Vinter Krešimir Kordić Iva Klobučar Ivo Darko Gabrić Marko Boban Matias Trbušić Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients Acta Clinica Croatica Acute myocardial infarction Left ventricular remodeling End-diastolic volume End-systolic volume |
| title | Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients |
| title_full | Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients |
| title_fullStr | Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients |
| title_full_unstemmed | Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients |
| title_short | Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients |
| title_sort | nomogram containing simple routine clinical and biochemical parameters can predict pathologic ventricular remodeling in stemi patients |
| topic | Acute myocardial infarction Left ventricular remodeling End-diastolic volume End-systolic volume |
| url | https://hrcak.srce.hr/file/393304 |
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