Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol
Biocidal coatings have been used in biomedicine, cosmetology and the food industry. In this article, the coatings are described as being composed of non-stoichiometric polycomplexes, products of electrostatic coupling of two commercial biodegradable ionic polymers, anionic sodium alginate and cation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14717 |
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| author | Olga A. Novoskoltseva Ekaterina A. Litmanovich Nataliya G. Loiko Yury A. Nikolaev Alexander A. Yaroslavov |
| author_facet | Olga A. Novoskoltseva Ekaterina A. Litmanovich Nataliya G. Loiko Yury A. Nikolaev Alexander A. Yaroslavov |
| author_sort | Olga A. Novoskoltseva |
| collection | DOAJ |
| description | Biocidal coatings have been used in biomedicine, cosmetology and the food industry. In this article, the coatings are described as being composed of non-stoichiometric polycomplexes, products of electrostatic coupling of two commercial biodegradable ionic polymers, anionic sodium alginate and cationic quaternized hydroxyethyl cellulose ethoxylate. Non-stoichiometric polycomplexes with a 5-fold excess of the cationic polymer were used for immobilizing hydrophobic biocidal 4-hexylresorcinol (HR). Being dispersed in water, the polycomplex particles were capable of absorbing a tenfold excess of HR in relation to the polycation. After deposition onto the plastic surface and drying, the aqueous polycomplex–HR composite formulation forms a transparent homogeneous coating, which swells slightly in water. The interpolyelectrolyte complex (IPEC) is substantially non-toxic. The incorporation of HR in the IPEC imparts antimicrobial activity to the resulting composite, in both aqueous solutions and coatings, against Gram-negative and Gram-positive bacteria and yeast. The polysaccharide-based polycomplexes with embedded HR are promising for the fabrication of biocidal films and coatings. |
| first_indexed | 2024-03-10T21:42:52Z |
| format | Article |
| id | doaj.art-85faef17c6e346fe9e56abde3509f674 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:42:52Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-85faef17c6e346fe9e56abde3509f6742023-11-19T14:30:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191471710.3390/ijms241914717Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-HexylresorcinolOlga A. Novoskoltseva0Ekaterina A. Litmanovich1Nataliya G. Loiko2Yury A. Nikolaev3Alexander A. Yaroslavov4Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Microbiology, Federal Research Center “Fundamentals of Biotechnology” RAS, 119071 Moscow, RussiaDepartment of Microbiology, Federal Research Center “Fundamentals of Biotechnology” RAS, 119071 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, RussiaBiocidal coatings have been used in biomedicine, cosmetology and the food industry. In this article, the coatings are described as being composed of non-stoichiometric polycomplexes, products of electrostatic coupling of two commercial biodegradable ionic polymers, anionic sodium alginate and cationic quaternized hydroxyethyl cellulose ethoxylate. Non-stoichiometric polycomplexes with a 5-fold excess of the cationic polymer were used for immobilizing hydrophobic biocidal 4-hexylresorcinol (HR). Being dispersed in water, the polycomplex particles were capable of absorbing a tenfold excess of HR in relation to the polycation. After deposition onto the plastic surface and drying, the aqueous polycomplex–HR composite formulation forms a transparent homogeneous coating, which swells slightly in water. The interpolyelectrolyte complex (IPEC) is substantially non-toxic. The incorporation of HR in the IPEC imparts antimicrobial activity to the resulting composite, in both aqueous solutions and coatings, against Gram-negative and Gram-positive bacteria and yeast. The polysaccharide-based polycomplexes with embedded HR are promising for the fabrication of biocidal films and coatings.https://www.mdpi.com/1422-0067/24/19/14717polysaccharideinterpolyelectrolyte complex4-hexylresorcinolcomposite coatingbiocidal activity |
| spellingShingle | Olga A. Novoskoltseva Ekaterina A. Litmanovich Nataliya G. Loiko Yury A. Nikolaev Alexander A. Yaroslavov Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol International Journal of Molecular Sciences polysaccharide interpolyelectrolyte complex 4-hexylresorcinol composite coating biocidal activity |
| title | Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol |
| title_full | Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol |
| title_fullStr | Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol |
| title_full_unstemmed | Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol |
| title_short | Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol |
| title_sort | biodegradable water soluble matrix for immobilization of biocidal 4 hexylresorcinol |
| topic | polysaccharide interpolyelectrolyte complex 4-hexylresorcinol composite coating biocidal activity |
| url | https://www.mdpi.com/1422-0067/24/19/14717 |
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