Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat
Introduction: Acinetobacter species has now been identified as a prime and notorious cause of nosocomial pneumonia and bloodstream infections, which is been observed especially among immunocompromised patients with underlying co morbidities or deliberating illnesses. Globally, there has been a signi...
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Gujarat Adani Institute of Medical Sciences
2022-12-01
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| Series: | GAIMS Journal of Medical Sciences |
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| Online Access: | https://gjms.gaims.ac.in/index.php/gjms/article/view/59/70 |
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| author | Hitesh Assudani Thiyagarajan Brihadishwwaran Krunal Mehta Krupali Kothari Shilpa Supekar Dolly Solanki |
| author_facet | Hitesh Assudani Thiyagarajan Brihadishwwaran Krunal Mehta Krupali Kothari Shilpa Supekar Dolly Solanki |
| author_sort | Hitesh Assudani |
| collection | DOAJ |
| description | Introduction: Acinetobacter species has now been identified as a prime and notorious cause of nosocomial pneumonia and bloodstream infections, which is been observed especially among immunocompromised patients with underlying co morbidities or deliberating illnesses. Globally, there has been a significant increase in resistance of this organism to most of the antimicrobials in recent period.
Aim: The aim of our study is to evaluate Acinetobacter isolates obtained from various clinical samples., their antimicrobial resistance pattern and changes in resistance pattern of the organism from the samples which they have been isolated from our tertiary care hospital.
Materials and Methods: In this study, Acinetobacter isolates were obtained from both the in-patients or out-patients during the period between 01.07.2021-01.07.2022 were used. The isolation and identification were done by using conventional methods. Antimicrobial susceptibility testing was done by Disc diffusion method as per CLSI guideline.
Results: More than 50% of isolates were found to be resistant to carbapenems such as Meropenem (60%) and Imipenem (55%) respectively; these antibiotics were used in our test battery. The isolates had exhibited a high level of resistance to the group of β-lactam combination antibiotics namely Piperacillin-Tazobactam (90%) and almost complete resistance to cephalosporins which were used in our testing battery at our laboratory. Moreover, they showed low level of resistance to ciprofloxacin among the fluoroquinolones group.
Conclusion: Our study showed high level of resistance to all available Antibiotics excluding colistin among Acinetobacter species. There has been an increased rate of complete drug-resistant isolates. In order to prevent development of multiple resistances, and produce maximum utility of the available limited antibiotic resources, each laboratory should determine the percentage of resistance to various Antibiotics among Acinetobacter species in different geographical region. |
| first_indexed | 2024-03-13T07:16:07Z |
| format | Article |
| id | doaj.art-85fc3e5e0c95466f936c4e86b64b9e4c |
| institution | Directory Open Access Journal |
| issn | 2583-1763 |
| language | English |
| last_indexed | 2024-03-13T07:16:07Z |
| publishDate | 2022-12-01 |
| publisher | Gujarat Adani Institute of Medical Sciences |
| record_format | Article |
| series | GAIMS Journal of Medical Sciences |
| spelling | doaj.art-85fc3e5e0c95466f936c4e86b64b9e4c2023-06-05T07:15:41ZengGujarat Adani Institute of Medical SciencesGAIMS Journal of Medical Sciences2583-17632022-12-01314910.5281/zenodo.7700734Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of GujaratHitesh Assudani0Thiyagarajan Brihadishwwaran1Krunal Mehta2Krupali Kothari3Shilpa Supekar4Dolly Solanki5Department of Microbiology, Gujarat Adani Institute of Medical Sciences and GK General Hospital, Bhuj, Kachchh, Gujarat-370001Department of Microbiology, Shri M P Shah Government Medical College, Jamnagar, Gujarat-361008Department of Microbiology, Shri M P Shah Government Medical College, Jamnagar, Gujarat-361008Department of Microbiology, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratDepartment of Microbiology, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratDepartment of Microbiology, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratIntroduction: Acinetobacter species has now been identified as a prime and notorious cause of nosocomial pneumonia and bloodstream infections, which is been observed especially among immunocompromised patients with underlying co morbidities or deliberating illnesses. Globally, there has been a significant increase in resistance of this organism to most of the antimicrobials in recent period. Aim: The aim of our study is to evaluate Acinetobacter isolates obtained from various clinical samples., their antimicrobial resistance pattern and changes in resistance pattern of the organism from the samples which they have been isolated from our tertiary care hospital. Materials and Methods: In this study, Acinetobacter isolates were obtained from both the in-patients or out-patients during the period between 01.07.2021-01.07.2022 were used. The isolation and identification were done by using conventional methods. Antimicrobial susceptibility testing was done by Disc diffusion method as per CLSI guideline. Results: More than 50% of isolates were found to be resistant to carbapenems such as Meropenem (60%) and Imipenem (55%) respectively; these antibiotics were used in our test battery. The isolates had exhibited a high level of resistance to the group of β-lactam combination antibiotics namely Piperacillin-Tazobactam (90%) and almost complete resistance to cephalosporins which were used in our testing battery at our laboratory. Moreover, they showed low level of resistance to ciprofloxacin among the fluoroquinolones group. Conclusion: Our study showed high level of resistance to all available Antibiotics excluding colistin among Acinetobacter species. There has been an increased rate of complete drug-resistant isolates. In order to prevent development of multiple resistances, and produce maximum utility of the available limited antibiotic resources, each laboratory should determine the percentage of resistance to various Antibiotics among Acinetobacter species in different geographical region.https://gjms.gaims.ac.in/index.php/gjms/article/view/59/70antibiotic susceptibility profileacinetobacter isolates |
| spellingShingle | Hitesh Assudani Thiyagarajan Brihadishwwaran Krunal Mehta Krupali Kothari Shilpa Supekar Dolly Solanki Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat GAIMS Journal of Medical Sciences antibiotic susceptibility profile acinetobacter isolates |
| title | Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat |
| title_full | Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat |
| title_fullStr | Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat |
| title_full_unstemmed | Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat |
| title_short | Antibiotic susceptibility profile of Acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in North western region of Gujarat |
| title_sort | antibiotic susceptibility profile of acinetobacter isolates isolated from various clinical specimens received at a tertiary care hospital in north western region of gujarat |
| topic | antibiotic susceptibility profile acinetobacter isolates |
| url | https://gjms.gaims.ac.in/index.php/gjms/article/view/59/70 |
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