Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity
AbstractThe sympathetic nervous system and the immune system are responsible for producing neurotransmitters and cytokines that interact by binding to receptors; due to this, there is communication between these systems. Liver immune cells and nerve fibres are systematically distributed in the liver...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2164047 |
| _version_ | 1827380543909527552 |
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| author | Mariana Yazmin Medina Pizaño María de Jesús Loera Arias Roberto Montes de Oca Luna Odila Saucedo Cárdenas Javier Ventura Juárez Martin Humberto Muñoz Ortega |
| author_facet | Mariana Yazmin Medina Pizaño María de Jesús Loera Arias Roberto Montes de Oca Luna Odila Saucedo Cárdenas Javier Ventura Juárez Martin Humberto Muñoz Ortega |
| author_sort | Mariana Yazmin Medina Pizaño |
| collection | DOAJ |
| description | AbstractThe sympathetic nervous system and the immune system are responsible for producing neurotransmitters and cytokines that interact by binding to receptors; due to this, there is communication between these systems. Liver immune cells and nerve fibres are systematically distributed in the liver, and the partial overlap of both patterns may favour interactions between certain elements. Dendritic cells are attached to fibroblasts, and nerve fibres are connected via the dendritic cell-fibroblast complex. Receptors for most neuroactive substances, such as catecholamines, have been discovered on dendritic cells. The sympathetic nervous system regulates hepatic fibrosis through sympathetic fibres and adrenaline from the adrenal glands through the blood. When there is liver damage, the sympathetic nervous system is activated locally and systemically through proinflammatory cytokines that induce the production of epinephrine and norepinephrine. These neurotransmitters bind to cells through α-adrenergic receptors, triggering a cellular response that secretes inflammatory factors that stimulate and activate hepatic stellate cells. Hepatic stellate cells are key in the fibrotic process. They initiate the overproduction of extracellular matrix components in an active state that progresses from fibrosis to liver cirrhosis. It has also been shown that they can be directly activated by norepinephrine. Alpha and beta adrenoblockers, such as carvedilol, prazosin, and doxazosin, have recently been used to reverse CCl4-induced liver cirrhosis in rodent and murine models.KEY MESSAGESNeurotransmitters from the sympathetic nervous system activate and increase the proliferation of hepatic stellate cells.Hepatic fibrosis and cirrhosis treatment might depend on neurotransmitter and hepatic nervous system regulation.Strategies to reduce hepatic stellate cell activation and fibrosis are based on experimentation with α-adrenoblockers. |
| first_indexed | 2024-03-08T13:35:30Z |
| format | Article |
| id | doaj.art-85fc3ee81ba146d08834533e84dd2d55 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:30Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-85fc3ee81ba146d08834533e84dd2d552024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155154355710.1080/07853890.2022.2164047Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activityMariana Yazmin Medina Pizaño0María de Jesús Loera Arias1Roberto Montes de Oca Luna2Odila Saucedo Cárdenas3Javier Ventura Juárez4Martin Humberto Muñoz Ortega5Histology Department, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, MéxicoHistology Department, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, MéxicoHistology Department, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, MéxicoHistology Department, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, MéxicoDepartment of Morphology, Autonomous University of Aguascalientes, Aguascalientes, MéxicoDepartment of Chemistry, Autonomous University of Aguascalientes, Aguascalientes, MéxicoAbstractThe sympathetic nervous system and the immune system are responsible for producing neurotransmitters and cytokines that interact by binding to receptors; due to this, there is communication between these systems. Liver immune cells and nerve fibres are systematically distributed in the liver, and the partial overlap of both patterns may favour interactions between certain elements. Dendritic cells are attached to fibroblasts, and nerve fibres are connected via the dendritic cell-fibroblast complex. Receptors for most neuroactive substances, such as catecholamines, have been discovered on dendritic cells. The sympathetic nervous system regulates hepatic fibrosis through sympathetic fibres and adrenaline from the adrenal glands through the blood. When there is liver damage, the sympathetic nervous system is activated locally and systemically through proinflammatory cytokines that induce the production of epinephrine and norepinephrine. These neurotransmitters bind to cells through α-adrenergic receptors, triggering a cellular response that secretes inflammatory factors that stimulate and activate hepatic stellate cells. Hepatic stellate cells are key in the fibrotic process. They initiate the overproduction of extracellular matrix components in an active state that progresses from fibrosis to liver cirrhosis. It has also been shown that they can be directly activated by norepinephrine. Alpha and beta adrenoblockers, such as carvedilol, prazosin, and doxazosin, have recently been used to reverse CCl4-induced liver cirrhosis in rodent and murine models.KEY MESSAGESNeurotransmitters from the sympathetic nervous system activate and increase the proliferation of hepatic stellate cells.Hepatic fibrosis and cirrhosis treatment might depend on neurotransmitter and hepatic nervous system regulation.Strategies to reduce hepatic stellate cell activation and fibrosis are based on experimentation with α-adrenoblockers.https://www.tandfonline.com/doi/10.1080/07853890.2022.2164047Cirrhosishepatic cellsstellate cellssympathetic nervous systemneuroimmunomodulationadrenoblockers |
| spellingShingle | Mariana Yazmin Medina Pizaño María de Jesús Loera Arias Roberto Montes de Oca Luna Odila Saucedo Cárdenas Javier Ventura Juárez Martin Humberto Muñoz Ortega Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity Annals of Medicine Cirrhosis hepatic cells stellate cells sympathetic nervous system neuroimmunomodulation adrenoblockers |
| title | Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity |
| title_full | Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity |
| title_fullStr | Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity |
| title_full_unstemmed | Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity |
| title_short | Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity |
| title_sort | neuroimmunomodulation of adrenoblockers during liver cirrhosis modulation of hepatic stellate cell activity |
| topic | Cirrhosis hepatic cells stellate cells sympathetic nervous system neuroimmunomodulation adrenoblockers |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2164047 |
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