Developing a cluster-based approach for deciphering complexity in individuals with neurodevelopmental differences

Developing a cluster-based approach for deciphering complexity in individuals with neurodevelopmental differences

ObjectiveIndividuals with neurodevelopmental disorders such as global developmental delay (GDD) present both genotypic and phenotypic heterogeneity. This diversity has hampered developing of targeted interventions given the relative rarity of each individual genetic etiology. Novel approaches to cli...

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Bibliographic Details
Main Authors: Tania Cuppens, Manpreet Kaur, Ajay A. Kumar, Julie Shatto, Andy Cheuk-Him Ng, Mickael Leclercq, Marek Z. Reformat, Arnaud Droit, Ian Dunham, François V. Bolduc
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pediatrics
Subjects:
neurodevelopmental differences
global developmental delay
phenotype
whole exome sequencing
hierarchical agglomerative clustering
k-means clustering
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2023.1171920/full

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