Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination
The initial months of life reflect an extremely challenging time for newborns as a naïve immune system is bombarded with a large array of pathogens, commensals, and other foreign entities. In many instances, the immune response of young infants is dampened or altered, resulting in increased suscepti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/8/4/558 |
| _version_ | 1797552763610071040 |
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| author | Kali F. Crofts Martha A. Alexander-Miller |
| author_facet | Kali F. Crofts Martha A. Alexander-Miller |
| author_sort | Kali F. Crofts |
| collection | DOAJ |
| description | The initial months of life reflect an extremely challenging time for newborns as a naïve immune system is bombarded with a large array of pathogens, commensals, and other foreign entities. In many instances, the immune response of young infants is dampened or altered, resulting in increased susceptibility and disease following infection. This is the result of both qualitative and quantitative changes in the response of multiple cell types across the immune system. Here we provide a review of the challenges associated with the newborn response to respiratory viral pathogens as well as the hurdles and advances for vaccine-mediated protection. |
| first_indexed | 2024-03-10T16:05:46Z |
| format | Article |
| id | doaj.art-85fe09906d7947b1baa0ce95c2739227 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T16:05:46Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-85fe09906d7947b1baa0ce95c27392272023-11-20T14:54:20ZengMDPI AGVaccines2076-393X2020-09-018455810.3390/vaccines8040558Challenges for the Newborn Immune Response to Respiratory Virus Infection and VaccinationKali F. Crofts0Martha A. Alexander-Miller1Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USADepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USAThe initial months of life reflect an extremely challenging time for newborns as a naïve immune system is bombarded with a large array of pathogens, commensals, and other foreign entities. In many instances, the immune response of young infants is dampened or altered, resulting in increased susceptibility and disease following infection. This is the result of both qualitative and quantitative changes in the response of multiple cell types across the immune system. Here we provide a review of the challenges associated with the newborn response to respiratory viral pathogens as well as the hurdles and advances for vaccine-mediated protection.https://www.mdpi.com/2076-393X/8/4/558newbornrespiratory virusesrespiratory infectionvaccinesinnate immunityadaptive immunity |
| spellingShingle | Kali F. Crofts Martha A. Alexander-Miller Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination Vaccines newborn respiratory viruses respiratory infection vaccines innate immunity adaptive immunity |
| title | Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination |
| title_full | Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination |
| title_fullStr | Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination |
| title_full_unstemmed | Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination |
| title_short | Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination |
| title_sort | challenges for the newborn immune response to respiratory virus infection and vaccination |
| topic | newborn respiratory viruses respiratory infection vaccines innate immunity adaptive immunity |
| url | https://www.mdpi.com/2076-393X/8/4/558 |
| work_keys_str_mv | AT kalifcrofts challengesforthenewbornimmuneresponsetorespiratoryvirusinfectionandvaccination AT marthaaalexandermiller challengesforthenewbornimmuneresponsetorespiratoryvirusinfectionandvaccination |