Early and severe cognitive impairment in multiple sclerosis
ABSTRACT Objectives: To report on four new cases of severe cognitive impairment in the early stages of multiple sclerosis (MS) and to review data on the subject since few cases have been reported worldwide. Methods: Retrospective evaluation of medical records of patients with severe cognitive im...
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642012000100048&lng=en&tlng=en |
| _version_ | 1819207304892907520 |
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| author | Maria Fernanda Mendes Alessandro Finkelsztejn Sidney Gomes Yára Dadalti Fragoso |
| author_facet | Maria Fernanda Mendes Alessandro Finkelsztejn Sidney Gomes Yára Dadalti Fragoso |
| author_sort | Maria Fernanda Mendes |
| collection | DOAJ |
| description | ABSTRACT Objectives: To report on four new cases of severe cognitive impairment in the early stages of multiple sclerosis (MS) and to review data on the subject since few cases have been reported worldwide. Methods: Retrospective evaluation of medical records of patients with severe cognitive impairment within the first five years of MS diagnosis. Results on neuropsychological tests and magnetic resonance imaging (MRI) were disclosed. Results: Four patients from different Brazilian neurological departments in Brazil were evaluated, all presenting with severe cognitive dysfunction classified as rapidly developing dementia. MRI images showed severe brain atrophy and basal ganglia lesions in all patients. Conclusions: Although rare, severe cognitive impairment in MS represents an important disability and may ultimately constitute another form of the disease. |
| first_indexed | 2024-12-23T05:21:22Z |
| format | Article |
| id | doaj.art-85fe4f689cc544a595ddd805847ff8b7 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-23T05:21:22Z |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-85fe4f689cc544a595ddd805847ff8b72022-12-21T17:58:42ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-576461485210.1590/S1980-57642012DN06010008S1980-57642012000100048Early and severe cognitive impairment in multiple sclerosisMaria Fernanda MendesAlessandro FinkelsztejnSidney GomesYára Dadalti FragosoABSTRACT Objectives: To report on four new cases of severe cognitive impairment in the early stages of multiple sclerosis (MS) and to review data on the subject since few cases have been reported worldwide. Methods: Retrospective evaluation of medical records of patients with severe cognitive impairment within the first five years of MS diagnosis. Results on neuropsychological tests and magnetic resonance imaging (MRI) were disclosed. Results: Four patients from different Brazilian neurological departments in Brazil were evaluated, all presenting with severe cognitive dysfunction classified as rapidly developing dementia. MRI images showed severe brain atrophy and basal ganglia lesions in all patients. Conclusions: Although rare, severe cognitive impairment in MS represents an important disability and may ultimately constitute another form of the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642012000100048&lng=en&tlng=enmultiple sclerosiscognitiondementiabasal gangliabrain atrophy |
| spellingShingle | Maria Fernanda Mendes Alessandro Finkelsztejn Sidney Gomes Yára Dadalti Fragoso Early and severe cognitive impairment in multiple sclerosis Dementia & Neuropsychologia multiple sclerosis cognition dementia basal ganglia brain atrophy |
| title | Early and severe cognitive impairment in multiple sclerosis |
| title_full | Early and severe cognitive impairment in multiple sclerosis |
| title_fullStr | Early and severe cognitive impairment in multiple sclerosis |
| title_full_unstemmed | Early and severe cognitive impairment in multiple sclerosis |
| title_short | Early and severe cognitive impairment in multiple sclerosis |
| title_sort | early and severe cognitive impairment in multiple sclerosis |
| topic | multiple sclerosis cognition dementia basal ganglia brain atrophy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642012000100048&lng=en&tlng=en |
| work_keys_str_mv | AT mariafernandamendes earlyandseverecognitiveimpairmentinmultiplesclerosis AT alessandrofinkelsztejn earlyandseverecognitiveimpairmentinmultiplesclerosis AT sidneygomes earlyandseverecognitiveimpairmentinmultiplesclerosis AT yaradadaltifragoso earlyandseverecognitiveimpairmentinmultiplesclerosis |