Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study
Objective: Cognitive impairments are common in Parkinson’s disease (PD) and can even occur in the early stages. The default mode network (DMN) is highly relevant for cognitive processes; however, it remains largely unknown if changes in the DMN connectivity are related to the cognitive decline in dr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00247/full |
| _version_ | 1818539305829662720 |
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| author | Yanbing Hou Jing Yang Chunyan Luo Wei Song Ruwei Ou Wanglin Liu Qiyong Gong Huifang Shang |
| author_facet | Yanbing Hou Jing Yang Chunyan Luo Wei Song Ruwei Ou Wanglin Liu Qiyong Gong Huifang Shang |
| author_sort | Yanbing Hou |
| collection | DOAJ |
| description | Objective: Cognitive impairments are common in Parkinson’s disease (PD) and can even occur in the early stages. The default mode network (DMN) is highly relevant for cognitive processes; however, it remains largely unknown if changes in the DMN connectivity are related to the cognitive decline in drug-naïve early-stage PD patients with a mild cognitive impairment (MCI). This study used resting-state functional MRI (fMRI) to explore the brain connectivity of the DMN in early-stage drug-naïve PD patients with MCI.Method: We recruited 32 early-stage drug-naïve PD patients and 22 matched healthy controls (HC). Among the PD patients, 14 were classified as having MCI (PD-MCI) and 18 were classified as having unimpaired cognition (PD-CU). The functional integration of the DMN was evaluated by a seed-based correlation approach.Results: The brain connectivity analysis revealed reduced functional connectivity (FC) in both PD subgroups compared with HC. The PD-MCI group showed a significant reduction in FC between the DMN and a set of regions, including the precentral gyrus, middle temporal gyrus, insula, anterior inferior parietal lobule and middle frontal gyrus. Compared to the PD-CU group, the PD-MCI group demonstrated a significantly decreased FC in the middle frontal and middle temporal gyri. Additionally, compared to HC, the PD-MCI group had a significantly decreased FC within the DMN, mainly in the FC between the hippocampal formation and inferior frontal gyrus, between the posterior cingulate cortex and posterior inferior parietal lobule, and between the anterior temporal lobe and inferior frontal gyrus. Compared to the PD-CU group, the only significantly decreased FC within the DMN in the PD-MCI group was between the anterior temporal lobe and inferior frontal gyrus. In all PD patients, the decreased FC between anterior temporal lobe and middle temporal gyrus was positively correlated with attention/working performance, and the reduced FC between the hippocampal formation and inferior frontal gyrus was also positively correlated with memory function.Conclusions: Our findings suggest that an altered DMN connectivity characterizes PD-MCI patients. These findings may be helpful for facilitating the further understanding of the potential mechanisms underlying MCI in PD. However, our results are preliminary, and further investigation is needed. |
| first_indexed | 2024-12-11T21:40:18Z |
| format | Article |
| id | doaj.art-8600fd945a474828936d0041eac92b7b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T21:40:18Z |
| publishDate | 2016-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8600fd945a474828936d0041eac92b7b2022-12-22T00:49:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-10-01810.3389/fnagi.2016.00247219785Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI studyYanbing Hou0Jing Yang1Chunyan Luo2Wei Song3Ruwei Ou4Wanglin Liu5Qiyong Gong6Huifang Shang7Sichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversityObjective: Cognitive impairments are common in Parkinson’s disease (PD) and can even occur in the early stages. The default mode network (DMN) is highly relevant for cognitive processes; however, it remains largely unknown if changes in the DMN connectivity are related to the cognitive decline in drug-naïve early-stage PD patients with a mild cognitive impairment (MCI). This study used resting-state functional MRI (fMRI) to explore the brain connectivity of the DMN in early-stage drug-naïve PD patients with MCI.Method: We recruited 32 early-stage drug-naïve PD patients and 22 matched healthy controls (HC). Among the PD patients, 14 were classified as having MCI (PD-MCI) and 18 were classified as having unimpaired cognition (PD-CU). The functional integration of the DMN was evaluated by a seed-based correlation approach.Results: The brain connectivity analysis revealed reduced functional connectivity (FC) in both PD subgroups compared with HC. The PD-MCI group showed a significant reduction in FC between the DMN and a set of regions, including the precentral gyrus, middle temporal gyrus, insula, anterior inferior parietal lobule and middle frontal gyrus. Compared to the PD-CU group, the PD-MCI group demonstrated a significantly decreased FC in the middle frontal and middle temporal gyri. Additionally, compared to HC, the PD-MCI group had a significantly decreased FC within the DMN, mainly in the FC between the hippocampal formation and inferior frontal gyrus, between the posterior cingulate cortex and posterior inferior parietal lobule, and between the anterior temporal lobe and inferior frontal gyrus. Compared to the PD-CU group, the only significantly decreased FC within the DMN in the PD-MCI group was between the anterior temporal lobe and inferior frontal gyrus. In all PD patients, the decreased FC between anterior temporal lobe and middle temporal gyrus was positively correlated with attention/working performance, and the reduced FC between the hippocampal formation and inferior frontal gyrus was also positively correlated with memory function.Conclusions: Our findings suggest that an altered DMN connectivity characterizes PD-MCI patients. These findings may be helpful for facilitating the further understanding of the potential mechanisms underlying MCI in PD. However, our results are preliminary, and further investigation is needed.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00247/fullMild Cognitive ImpairmentfMRIDefault Mode Networkfunctional connectivityParkinson’s disease |
| spellingShingle | Yanbing Hou Jing Yang Chunyan Luo Wei Song Ruwei Ou Wanglin Liu Qiyong Gong Huifang Shang Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study Frontiers in Aging Neuroscience Mild Cognitive Impairment fMRI Default Mode Network functional connectivity Parkinson’s disease |
| title | Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study |
| title_full | Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study |
| title_fullStr | Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study |
| title_full_unstemmed | Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study |
| title_short | Dysfunction of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state fMRI study |
| title_sort | dysfunction of the default mode network in drug na 239 ve parkinson s disease with mild cognitive impairments a resting state fmri study |
| topic | Mild Cognitive Impairment fMRI Default Mode Network functional connectivity Parkinson’s disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00247/full |
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