Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis
Introduction: Two mRNA vaccines approved in the U.S. have high efficacy against COVID-19 disease from the original strain of SARS-CoV-2. We evaluated the population-level association between vaccination status and COVID-19 infection by age group during the initial wave of the Omicron variant in a di...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | AJPM Focus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773065422000098 |
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| author | Allison P. Plaxco, MPH Jennifer M. Kmet, MPH Vikki G. Nolan, MPH, DSc Michelle A. Taylor, MD, DrPH, MPA Matthew P. Smeltzer, MStat, PhD |
| author_facet | Allison P. Plaxco, MPH Jennifer M. Kmet, MPH Vikki G. Nolan, MPH, DSc Michelle A. Taylor, MD, DrPH, MPA Matthew P. Smeltzer, MStat, PhD |
| author_sort | Allison P. Plaxco, MPH |
| collection | DOAJ |
| description | Introduction: Two mRNA vaccines approved in the U.S. have high efficacy against COVID-19 disease from the original strain of SARS-CoV-2. We evaluated the population-level association between vaccination status and COVID-19 infection by age group during the initial wave of the Omicron variant in a diverse population in the Mid-South U.S. Methods: In this observational population-based cohort study, vaccination information and positive COVID-19 cases in Shelby County, Tennessee, from December 12, 2021 through January 22, 2022 were collected from surveillance data at the Shelby County Health Department (Memphis, Tennessee). Exposure groups included individuals who were unvaccinated, were fully vaccinated, and were fully vaccinated + booster. We calculated incidence rates of COVID-19 diagnosis per person-year among county adult (aged 18+ years) residents in crude form and stratified by age group. Results: In this population-based study, we identified 64.56% fewer COVID-19 infections in the fully vaccinated + booster group and 41.08% fewer in the fully vaccinated group than in the unvaccinated group. Conclusions: These results confirm and extend the findings of recent immunologic and epidemiologic studies in a racially diverse region of the Mid-South U.S. In stratified analysis, we also found evidence suggesting that vaccine protection against Omicron may increase with age. |
| first_indexed | 2024-04-11T08:18:14Z |
| format | Article |
| id | doaj.art-8601d7a67aba4a56b87051f9b22b3824 |
| institution | Directory Open Access Journal |
| issn | 2773-0654 |
| language | English |
| last_indexed | 2024-04-11T08:18:14Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJPM Focus |
| spelling | doaj.art-8601d7a67aba4a56b87051f9b22b38242022-12-22T04:35:04ZengElsevierAJPM Focus2773-06542022-09-0111100010Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level AnalysisAllison P. Plaxco, MPH0Jennifer M. Kmet, MPH1Vikki G. Nolan, MPH, DSc2Michelle A. Taylor, MD, DrPH, MPA3Matthew P. Smeltzer, MStat, PhD4Bureau of Epidemiology, Preparedness & Informatics, Shelby County Health Department, Memphis, Tennessee; COVID-19 Response Unit, Shelby County Health Department, Memphis, Tennessee; Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TennesseeBureau of Epidemiology, Preparedness & Informatics, Shelby County Health Department, Memphis, Tennessee; COVID-19 Response Unit, Shelby County Health Department, Memphis, TennesseeDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TennesseeBureau of Epidemiology, Preparedness & Informatics, Shelby County Health Department, Memphis, Tennessee; COVID-19 Response Unit, Shelby County Health Department, Memphis, TennesseeDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, Tennessee; Address correspondence to: Matthew P. Smeltzer, MStat, PhD, Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, 222 Robison Hall, Memphis TN 38152.Introduction: Two mRNA vaccines approved in the U.S. have high efficacy against COVID-19 disease from the original strain of SARS-CoV-2. We evaluated the population-level association between vaccination status and COVID-19 infection by age group during the initial wave of the Omicron variant in a diverse population in the Mid-South U.S. Methods: In this observational population-based cohort study, vaccination information and positive COVID-19 cases in Shelby County, Tennessee, from December 12, 2021 through January 22, 2022 were collected from surveillance data at the Shelby County Health Department (Memphis, Tennessee). Exposure groups included individuals who were unvaccinated, were fully vaccinated, and were fully vaccinated + booster. We calculated incidence rates of COVID-19 diagnosis per person-year among county adult (aged 18+ years) residents in crude form and stratified by age group. Results: In this population-based study, we identified 64.56% fewer COVID-19 infections in the fully vaccinated + booster group and 41.08% fewer in the fully vaccinated group than in the unvaccinated group. Conclusions: These results confirm and extend the findings of recent immunologic and epidemiologic studies in a racially diverse region of the Mid-South U.S. In stratified analysis, we also found evidence suggesting that vaccine protection against Omicron may increase with age.http://www.sciencedirect.com/science/article/pii/S2773065422000098mRNACOVID-19vaccineOmicron variant |
| spellingShingle | Allison P. Plaxco, MPH Jennifer M. Kmet, MPH Vikki G. Nolan, MPH, DSc Michelle A. Taylor, MD, DrPH, MPA Matthew P. Smeltzer, MStat, PhD Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis AJPM Focus mRNA COVID-19 vaccine Omicron variant |
| title | Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis |
| title_full | Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis |
| title_fullStr | Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis |
| title_full_unstemmed | Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis |
| title_short | Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis |
| title_sort | real world association between mrna vaccination and infection from the omicron strain of sars cov 2 a population level analysis |
| topic | mRNA COVID-19 vaccine Omicron variant |
| url | http://www.sciencedirect.com/science/article/pii/S2773065422000098 |
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