Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats
Abstract Purpose Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status. Methods Eighty female wistar rats were divid...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-017-0288-z |
| _version_ | 1828188183138926592 |
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| author | Parvin Babaei Samaneh Ghorbani Shirkouhi Rastegar Hosseini Bahram Soltani Tehrani |
| author_facet | Parvin Babaei Samaneh Ghorbani Shirkouhi Rastegar Hosseini Bahram Soltani Tehrani |
| author_sort | Parvin Babaei |
| collection | DOAJ |
| description | Abstract Purpose Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status. Methods Eighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE − D), and (OVX + EXE + Veh). Also non exercised groups of OVX receiving high dose of Vit D (OVX + HD), low dose of Vit D (OVX + LD), Vit D deficiency (OVX − D), and Veh (OVX + Veh) were included. After 2 months of related interventions, spatial memory was assessed using Morris water maze (MWM), and then metabolic syndrome components were measured. Results High dose of Vit D supplementation showed significant reduction in weight (p = 0.001), lipid profiles (p = 0.001), visceral fat (p = 0.001) and waist circumference (p = 0.001) regardless of exercising or not, with no change in cognitiive function. Serum BDNF level was significantly higher in Vit D deficient group (p = 0.001), and was decreased in the OVX + HD. In contrary, irisin did not show any significant relationship with serum concentration of Vit D, while it was significantly elevated in the exercised groups compared with non-exercised counterparts. Conclusion Vit D insufficiency deteriorates metabolic syndrome components, and elevates serum BDNF as a compensatory metabotropic factor, and further supplementation significantly attenuates these components parallel with reduction in BDNF. In addition, aerobic exercise successfully induces various metabolic benefits, provided optimum serum level of Vit D. |
| first_indexed | 2024-04-12T07:46:44Z |
| format | Article |
| id | doaj.art-8603400ab59046508906b97489ad03c1 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-12T07:46:44Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-8603400ab59046508906b97489ad03c12022-12-22T03:41:41ZengBMCDiabetology & Metabolic Syndrome1758-59962017-11-01911910.1186/s13098-017-0288-zVitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized ratsParvin Babaei0Samaneh Ghorbani Shirkouhi1Rastegar Hosseini2Bahram Soltani Tehrani3Cellular & Molecular Research Center, Faculty of Medicine, Guilan University of Medical SciencesCellular & Molecular Research Center, Faculty of Medicine, Guilan University of Medical SciencesDepartment of Exercise Physiology, Faculty of Sport Sciences, Razi UniversityCellular & Molecular Research Center, Faculty of Medicine, Guilan University of Medical SciencesAbstract Purpose Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status. Methods Eighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE − D), and (OVX + EXE + Veh). Also non exercised groups of OVX receiving high dose of Vit D (OVX + HD), low dose of Vit D (OVX + LD), Vit D deficiency (OVX − D), and Veh (OVX + Veh) were included. After 2 months of related interventions, spatial memory was assessed using Morris water maze (MWM), and then metabolic syndrome components were measured. Results High dose of Vit D supplementation showed significant reduction in weight (p = 0.001), lipid profiles (p = 0.001), visceral fat (p = 0.001) and waist circumference (p = 0.001) regardless of exercising or not, with no change in cognitiive function. Serum BDNF level was significantly higher in Vit D deficient group (p = 0.001), and was decreased in the OVX + HD. In contrary, irisin did not show any significant relationship with serum concentration of Vit D, while it was significantly elevated in the exercised groups compared with non-exercised counterparts. Conclusion Vit D insufficiency deteriorates metabolic syndrome components, and elevates serum BDNF as a compensatory metabotropic factor, and further supplementation significantly attenuates these components parallel with reduction in BDNF. In addition, aerobic exercise successfully induces various metabolic benefits, provided optimum serum level of Vit D.http://link.springer.com/article/10.1186/s13098-017-0288-zMetabolic syndromeMemoryVitamin DBDNFIrisinAerobic exercise |
| spellingShingle | Parvin Babaei Samaneh Ghorbani Shirkouhi Rastegar Hosseini Bahram Soltani Tehrani Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats Diabetology & Metabolic Syndrome Metabolic syndrome Memory Vitamin D BDNF Irisin Aerobic exercise |
| title | Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats |
| title_full | Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats |
| title_fullStr | Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats |
| title_full_unstemmed | Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats |
| title_short | Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats |
| title_sort | vitamin d is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats |
| topic | Metabolic syndrome Memory Vitamin D BDNF Irisin Aerobic exercise |
| url | http://link.springer.com/article/10.1186/s13098-017-0288-z |
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