The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
Abstract Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our un...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41542-w |
| _version_ | 1797558318994030592 |
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| author | Sean Cavany Stella Nanyonga Cathrin Hauk Cherry Lim Joel Tarning Benn Sartorius Christiane Dolecek Céline Caillet Paul N. Newton Ben S. Cooper |
| author_facet | Sean Cavany Stella Nanyonga Cathrin Hauk Cherry Lim Joel Tarning Benn Sartorius Christiane Dolecek Céline Caillet Paul N. Newton Ben S. Cooper |
| author_sort | Sean Cavany |
| collection | DOAJ |
| description | Abstract Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understanding of this relationship remains rudimentary. Substandard and falsified medicines have the potential to either increase or decrease levels of resistance, and here we discuss a range of mechanisms that could drive these changes. Understanding these effects and their relative importance will require an improved understanding of how different drug exposures affect the emergence and spread of resistance and of how the percentage of active pharmaceutical ingredients in substandard and falsified medicines is temporally and spatially distributed. |
| first_indexed | 2024-03-10T17:29:49Z |
| format | Article |
| id | doaj.art-860426eaee644f83b3abb09caabe2c8b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:29:49Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-860426eaee644f83b3abb09caabe2c8b2023-11-20T10:04:00ZengNature PortfolioNature Communications2041-17232023-10-011411910.1038/s41467-023-41542-wThe uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistanceSean Cavany0Stella Nanyonga1Cathrin Hauk2Cherry Lim3Joel Tarning4Benn Sartorius5Christiane Dolecek6Céline Caillet7Paul N. Newton8Ben S. Cooper9NDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of OxfordAbstract Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understanding of this relationship remains rudimentary. Substandard and falsified medicines have the potential to either increase or decrease levels of resistance, and here we discuss a range of mechanisms that could drive these changes. Understanding these effects and their relative importance will require an improved understanding of how different drug exposures affect the emergence and spread of resistance and of how the percentage of active pharmaceutical ingredients in substandard and falsified medicines is temporally and spatially distributed.https://doi.org/10.1038/s41467-023-41542-w |
| spellingShingle | Sean Cavany Stella Nanyonga Cathrin Hauk Cherry Lim Joel Tarning Benn Sartorius Christiane Dolecek Céline Caillet Paul N. Newton Ben S. Cooper The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance Nature Communications |
| title | The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance |
| title_full | The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance |
| title_fullStr | The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance |
| title_full_unstemmed | The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance |
| title_short | The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance |
| title_sort | uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance |
| url | https://doi.org/10.1038/s41467-023-41542-w |
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