Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study
Abstract Muscle size and composition (muscle volume and muscle fat infiltrate [MFI]) may provide insight into possible mechanisms underpinning chronic idiopathic neck pain, a common condition with no definitive underlying pathology. In individuals with chronic idiopathic neck pain > 3 months and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-022-05924-3 |
| _version_ | 1828098617354747904 |
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| author | Suzanne J Snodgrass Peter Stanwell Kenneth A. Weber Samala Shepherd Olivia Kennedy Hannah J Thompson James M Elliott |
| author_facet | Suzanne J Snodgrass Peter Stanwell Kenneth A. Weber Samala Shepherd Olivia Kennedy Hannah J Thompson James M Elliott |
| author_sort | Suzanne J Snodgrass |
| collection | DOAJ |
| description | Abstract Muscle size and composition (muscle volume and muscle fat infiltrate [MFI]) may provide insight into possible mechanisms underpinning chronic idiopathic neck pain, a common condition with no definitive underlying pathology. In individuals with chronic idiopathic neck pain > 3 months and age- and sex-matched asymptomatic controls, muscle volumes of levator scapulae, multifidus including semispinalis cervicis (MFSS), semispinalis capitis, splenius capitis including splenius cervicis (SCSC), sternocleidomastoid and longus colli from C3 through T1 were quantified from magnetic resonance imaging. Between-group differences were determined using linear mixed models, accounting for side (left or right), muscle, spinal level, sex, age, and body mass index (BMI). Individuals with pain had greater muscle volume (mean difference 76.8mm3; 95% CI 26.6–127.0; p = .003) and MFI (2.3%; 0.2–4.5; p = .034) of the MFSS compared to matched controls with no differences in relative volume, accounting for factors associated with the outcomes: muscle, spinal level, side (left had smaller volume, relative volume and MFI than right), sex (females had less volume and relative volume than males), age (older age associated with less relative volume and greater MFI), and BMI (higher BMI associated with greater muscle volume and MFI). Greater MFI in individuals with chronic idiopathic neck pain suggests a possible underlying mechanism contributing to neck pain. Perspective: These findings suggest MFI in the MFSS may be radiologic sign, potentially identifying patients with a less favourable prognosis. Future studies are needed to confirm this finding and determine if MFI is a contributor to the development or persistence of neck pain, or consequence of neck pain. |
| first_indexed | 2024-04-11T08:03:46Z |
| format | Article |
| id | doaj.art-86043903b31e40d58f8e25ee65870f45 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-11T08:03:46Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-86043903b31e40d58f8e25ee65870f452022-12-22T04:35:37ZengBMCBMC Musculoskeletal Disorders1471-24742022-11-0123111210.1186/s12891-022-05924-3Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional studySuzanne J Snodgrass0Peter Stanwell1Kenneth A. Weber2Samala Shepherd3Olivia Kennedy4Hannah J Thompson5James M Elliott6School of Health Sciences, The University of NewcastleSchool of Health Sciences, The University of NewcastleDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of MedicineSchool of Health Sciences, The University of NewcastleSchool of Health Sciences, The University of NewcastleSchool of Health Sciences, The University of NewcastleThe University of Sydney, Faculty of Medicine and Health & The Northern Sydney Local Health District - The Kolling Institute, Level 13Abstract Muscle size and composition (muscle volume and muscle fat infiltrate [MFI]) may provide insight into possible mechanisms underpinning chronic idiopathic neck pain, a common condition with no definitive underlying pathology. In individuals with chronic idiopathic neck pain > 3 months and age- and sex-matched asymptomatic controls, muscle volumes of levator scapulae, multifidus including semispinalis cervicis (MFSS), semispinalis capitis, splenius capitis including splenius cervicis (SCSC), sternocleidomastoid and longus colli from C3 through T1 were quantified from magnetic resonance imaging. Between-group differences were determined using linear mixed models, accounting for side (left or right), muscle, spinal level, sex, age, and body mass index (BMI). Individuals with pain had greater muscle volume (mean difference 76.8mm3; 95% CI 26.6–127.0; p = .003) and MFI (2.3%; 0.2–4.5; p = .034) of the MFSS compared to matched controls with no differences in relative volume, accounting for factors associated with the outcomes: muscle, spinal level, side (left had smaller volume, relative volume and MFI than right), sex (females had less volume and relative volume than males), age (older age associated with less relative volume and greater MFI), and BMI (higher BMI associated with greater muscle volume and MFI). Greater MFI in individuals with chronic idiopathic neck pain suggests a possible underlying mechanism contributing to neck pain. Perspective: These findings suggest MFI in the MFSS may be radiologic sign, potentially identifying patients with a less favourable prognosis. Future studies are needed to confirm this finding and determine if MFI is a contributor to the development or persistence of neck pain, or consequence of neck pain.https://doi.org/10.1186/s12891-022-05924-3Neck musclesMuscle, skeletalNeck painMusculoskeletal painChronic pain |
| spellingShingle | Suzanne J Snodgrass Peter Stanwell Kenneth A. Weber Samala Shepherd Olivia Kennedy Hannah J Thompson James M Elliott Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study BMC Musculoskeletal Disorders Neck muscles Muscle, skeletal Neck pain Musculoskeletal pain Chronic pain |
| title | Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study |
| title_full | Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study |
| title_fullStr | Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study |
| title_full_unstemmed | Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study |
| title_short | Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study |
| title_sort | greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles multifidus with semispinalis cervicis in individuals with chronic idiopathic neck pain compared to age and sex matched asymptomatic controls a cross sectional study |
| topic | Neck muscles Muscle, skeletal Neck pain Musculoskeletal pain Chronic pain |
| url | https://doi.org/10.1186/s12891-022-05924-3 |
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