Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms
BackgroundNeuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropatholog...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.875059/full |
| _version_ | 1811200048657072128 |
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| author | Dan-ning Li Teng-hong Lian Wei-Jiao Zhang Ya-nan Zhang Peng Guo Hui-ying Guan Jing-hui Li Ming-yue He Wen-jing Zhang Wei-jia Zhang Dong-mei Luo Xiao-min Wang Wei Zhang Wei Zhang Wei Zhang Wei Zhang |
| author_facet | Dan-ning Li Teng-hong Lian Wei-Jiao Zhang Ya-nan Zhang Peng Guo Hui-ying Guan Jing-hui Li Ming-yue He Wen-jing Zhang Wei-jia Zhang Dong-mei Luo Xiao-min Wang Wei Zhang Wei Zhang Wei Zhang Wei Zhang |
| author_sort | Dan-ning Li |
| collection | DOAJ |
| description | BackgroundNeuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropathological proteins in cerebrospinal fluid (CSF) in patients with PD, aiming to provide insights into the potential mechanisms and therapeutic target for PD with NPSs (PD-NPSs).MethodsIn total, 129 patients with PD were enrolled and assessed by the Neuropsychiatric Symptoms Inventory (NPI); they were divided into the PD-NPSs group (75 patients) and PD with no NPSs (PD-nNPSs) group (54 patients). The levels of hydrogen peroxide (H2O2) and nitric oxide (NO), and hydroxyl radical (·OH), anti-oxidative enzyme, neuroinflammatory factors, and neuropathological proteins in CSF from patients with PD were measured. The levels of the above variables were compared between PD-NPSs and PD-nNPSs groups, and correlation analyses among the above variables were conducted.Results(1) The levels of H2O2 and NO in CSF from the PD-NPSs group were significantly elevated compared with the PD-nNPSs group (p = 0.001), and NPI score positively correlated with the levels of H2O2 and NO (r = 0.283, P = 0.001; r = 0.231, P = 0.008). Reversely, total superoxide dismutase (tSOD) activity in CSF from the PD-NPSs group was significantly reduced compared with the PD-nNPSs group (p = 0.011), and negatively correlated with NPI score (r = −0.185, p = 0.036). (2) The tumor necrosis factor (TNF)-α level in CSF from the PD-NPSs group was significantly decreased compared with the PD-nNPSs group (p = 0.002) and negatively correlated with NPI score (r = −0.211, p = 0.016). (3) The total tau (T-tau) level in CSF from the PD-NPSs group was significantly higher than in the PD-nNPSs group (p = 0.014) and positively correlated with the NPI score (r = 0.167, p = 0.060). (4) The levels of H2O2 and NO positively correlated with the T-tau level in CSF from the PD-NPSs group (r = 0.183, p = 0.039; r = 0.251, P = 0.004), and the levels of TNF-α and T-tau showed a negative correlation (r = −0.163, p = 0.067).ConclusionOxidative distress characterized by the elevations of H2O2 and NO levels may closely correlate with the neurodegeneration in brain regions related to PD-NPSs. Thus, therapeutic antioxidants may become an important target for PD-NPSs therapy. |
| first_indexed | 2024-04-12T01:58:08Z |
| format | Article |
| id | doaj.art-8607520376914362999f4ca9235ae2b6 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T01:58:08Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8607520376914362999f4ca9235ae2b62022-12-22T03:52:45ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-12-011410.3389/fnagi.2022.875059875059Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptomsDan-ning Li0Teng-hong Lian1Wei-Jiao Zhang2Ya-nan Zhang3Peng Guo4Hui-ying Guan5Jing-hui Li6Ming-yue He7Wen-jing Zhang8Wei-jia Zhang9Dong-mei Luo10Xiao-min Wang11Wei Zhang12Wei Zhang13Wei Zhang14Wei Zhang15Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Blood Transfusion, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Physiology, Capital Medical University, Beijing, ChinaCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory on Parkinson's Disease, Beijing, ChinaBackgroundNeuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropathological proteins in cerebrospinal fluid (CSF) in patients with PD, aiming to provide insights into the potential mechanisms and therapeutic target for PD with NPSs (PD-NPSs).MethodsIn total, 129 patients with PD were enrolled and assessed by the Neuropsychiatric Symptoms Inventory (NPI); they were divided into the PD-NPSs group (75 patients) and PD with no NPSs (PD-nNPSs) group (54 patients). The levels of hydrogen peroxide (H2O2) and nitric oxide (NO), and hydroxyl radical (·OH), anti-oxidative enzyme, neuroinflammatory factors, and neuropathological proteins in CSF from patients with PD were measured. The levels of the above variables were compared between PD-NPSs and PD-nNPSs groups, and correlation analyses among the above variables were conducted.Results(1) The levels of H2O2 and NO in CSF from the PD-NPSs group were significantly elevated compared with the PD-nNPSs group (p = 0.001), and NPI score positively correlated with the levels of H2O2 and NO (r = 0.283, P = 0.001; r = 0.231, P = 0.008). Reversely, total superoxide dismutase (tSOD) activity in CSF from the PD-NPSs group was significantly reduced compared with the PD-nNPSs group (p = 0.011), and negatively correlated with NPI score (r = −0.185, p = 0.036). (2) The tumor necrosis factor (TNF)-α level in CSF from the PD-NPSs group was significantly decreased compared with the PD-nNPSs group (p = 0.002) and negatively correlated with NPI score (r = −0.211, p = 0.016). (3) The total tau (T-tau) level in CSF from the PD-NPSs group was significantly higher than in the PD-nNPSs group (p = 0.014) and positively correlated with the NPI score (r = 0.167, p = 0.060). (4) The levels of H2O2 and NO positively correlated with the T-tau level in CSF from the PD-NPSs group (r = 0.183, p = 0.039; r = 0.251, P = 0.004), and the levels of TNF-α and T-tau showed a negative correlation (r = −0.163, p = 0.067).ConclusionOxidative distress characterized by the elevations of H2O2 and NO levels may closely correlate with the neurodegeneration in brain regions related to PD-NPSs. Thus, therapeutic antioxidants may become an important target for PD-NPSs therapy.https://www.frontiersin.org/articles/10.3389/fnagi.2022.875059/fullParkinson's diseaseneuropsychiatric symptomsfree radicalsanti-oxidative enzymeneuropathological proteinscerebrospinal fluid |
| spellingShingle | Dan-ning Li Teng-hong Lian Wei-Jiao Zhang Ya-nan Zhang Peng Guo Hui-ying Guan Jing-hui Li Ming-yue He Wen-jing Zhang Wei-jia Zhang Dong-mei Luo Xiao-min Wang Wei Zhang Wei Zhang Wei Zhang Wei Zhang Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms Frontiers in Aging Neuroscience Parkinson's disease neuropsychiatric symptoms free radicals anti-oxidative enzyme neuropathological proteins cerebrospinal fluid |
| title | Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms |
| title_full | Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms |
| title_fullStr | Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms |
| title_full_unstemmed | Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms |
| title_short | Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms |
| title_sort | potential roles of oxidative distress on neurodegeneration in parkinson s disease with neuropsychiatric symptoms |
| topic | Parkinson's disease neuropsychiatric symptoms free radicals anti-oxidative enzyme neuropathological proteins cerebrospinal fluid |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.875059/full |
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