Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin

Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin

ABSTRACTDuring blood-stage infection, Plasmodium falciparum parasites are constantly exposed to a range of extracellular stimuli, including host molecules and drugs such as artemisinin derivatives, the mainstay of artemisinin-based combination therapies currently used as first-line treatment worldwi...

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Bibliographic Details
Main Authors: Lucien Platon, Didier Leroy, David A. Fidock, Didier Ménard
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
malaria
P. falciparum
ring stages
temporary cell growth arrest
artemisinin resistance
intercellular communication
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03500-23

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