Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review
Objective: To evaluate the role of neoadjuvant chemotherapy (NACT) in the management of advanced ovarian cancer (AOC), with a focus on patient eligibility, pre-NACT diagnosis, treatment, timing of interval cytoreductive surgery (ICS) and the target of ICS, challenges in ICS, response assessment, cha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-11-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011246 |
| _version_ | 1797401024004096000 |
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| author | Jiaxi Li Jitong Zhao Shuying Liao Ce Bian |
| author_facet | Jiaxi Li Jitong Zhao Shuying Liao Ce Bian |
| author_sort | Jiaxi Li |
| collection | DOAJ |
| description | Objective: To evaluate the role of neoadjuvant chemotherapy (NACT) in the management of advanced ovarian cancer (AOC), with a focus on patient eligibility, pre-NACT diagnosis, treatment, timing of interval cytoreductive surgery (ICS) and the target of ICS, challenges in ICS, response assessment, changes in the tumor microenvironment during NACT, platinum resistance. Mechanism: NACT precedes cytoreductive surgery and shrinks tumors, thereby improving surgical success. Findings in Brief: NACT shows promising results for improving tumor reduction rates and improve prognosis. Conclusions: NACT has emerged as a promising treatment strategy for AOC. |
| first_indexed | 2024-03-09T02:02:57Z |
| format | Article |
| id | doaj.art-8608182dec604527ac24ba007838b131 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-09T02:02:57Z |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-8608182dec604527ac24ba007838b1312023-12-08T02:49:17ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-11-01501124610.31083/j.ceog5011246S0390-6663(23)02238-8Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A ReviewJiaxi Li0Jitong Zhao1Shuying Liao2Ce Bian3Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaObjective: To evaluate the role of neoadjuvant chemotherapy (NACT) in the management of advanced ovarian cancer (AOC), with a focus on patient eligibility, pre-NACT diagnosis, treatment, timing of interval cytoreductive surgery (ICS) and the target of ICS, challenges in ICS, response assessment, changes in the tumor microenvironment during NACT, platinum resistance. Mechanism: NACT precedes cytoreductive surgery and shrinks tumors, thereby improving surgical success. Findings in Brief: NACT shows promising results for improving tumor reduction rates and improve prognosis. Conclusions: NACT has emerged as a promising treatment strategy for AOC.https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011246advanced stage ovarian cancerneoadjuvant chemotherapyinterval cytoreductive surgery |
| spellingShingle | Jiaxi Li Jitong Zhao Shuying Liao Ce Bian Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review Clinical and Experimental Obstetrics & Gynecology advanced stage ovarian cancer neoadjuvant chemotherapy interval cytoreductive surgery |
| title | Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review |
| title_full | Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review |
| title_fullStr | Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review |
| title_full_unstemmed | Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review |
| title_short | Current Status and Controversies in Neoadjuvant Chemotherapy for Advanced Stage Ovarian Cancer: A Review |
| title_sort | current status and controversies in neoadjuvant chemotherapy for advanced stage ovarian cancer a review |
| topic | advanced stage ovarian cancer neoadjuvant chemotherapy interval cytoreductive surgery |
| url | https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011246 |
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