The role of glycogen synthase kinase 3 beta in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individuals worldwide. NDDs include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and so on. They are characterized...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1209703/full |
| _version_ | 1827816696360992768 |
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| author | Honglu Yu Min Xiong Zhentao Zhang Zhentao Zhang |
| author_facet | Honglu Yu Min Xiong Zhentao Zhang Zhentao Zhang |
| author_sort | Honglu Yu |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individuals worldwide. NDDs include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and so on. They are characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system and share several cellular and molecular mechanisms, including protein aggregation, mitochondrial dysfunction, gene mutations, and chronic neuroinflammation. Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase that is believed to play a pivotal role in the pathogenesis of NDDs. Here we summarize the structure and physiological functions of GSK3β and explore its involvement in NDDs. We also discussed its potential as a therapeutic target. |
| first_indexed | 2024-03-12T00:23:10Z |
| format | Article |
| id | doaj.art-860b98a3d04b457f8ed080eab778f06b |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-12T00:23:10Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-860b98a3d04b457f8ed080eab778f06b2023-09-15T11:58:53ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-09-011610.3389/fnmol.2023.12097031209703The role of glycogen synthase kinase 3 beta in neurodegenerative diseasesHonglu Yu0Min Xiong1Zhentao Zhang2Zhentao Zhang3Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaTaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaNeurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individuals worldwide. NDDs include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and so on. They are characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system and share several cellular and molecular mechanisms, including protein aggregation, mitochondrial dysfunction, gene mutations, and chronic neuroinflammation. Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase that is believed to play a pivotal role in the pathogenesis of NDDs. Here we summarize the structure and physiological functions of GSK3β and explore its involvement in NDDs. We also discussed its potential as a therapeutic target.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1209703/fullprotein aggregationAlzheimer’s diseaseParkinson’s diseaseHuntington’s diseaseamyotrophic lateral sclerosis |
| spellingShingle | Honglu Yu Min Xiong Zhentao Zhang Zhentao Zhang The role of glycogen synthase kinase 3 beta in neurodegenerative diseases Frontiers in Molecular Neuroscience protein aggregation Alzheimer’s disease Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis |
| title | The role of glycogen synthase kinase 3 beta in neurodegenerative diseases |
| title_full | The role of glycogen synthase kinase 3 beta in neurodegenerative diseases |
| title_fullStr | The role of glycogen synthase kinase 3 beta in neurodegenerative diseases |
| title_full_unstemmed | The role of glycogen synthase kinase 3 beta in neurodegenerative diseases |
| title_short | The role of glycogen synthase kinase 3 beta in neurodegenerative diseases |
| title_sort | role of glycogen synthase kinase 3 beta in neurodegenerative diseases |
| topic | protein aggregation Alzheimer’s disease Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1209703/full |
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