Deletion of Seipin Attenuates Vascular Function and the Anticontractile Effect of Perivascular Adipose Tissue

Deletion of Seipin Attenuates Vascular Function and the Anticontractile Effect of Perivascular Adipose Tissue

Seipin locates in endoplasmic reticulum (ER) and regulates adipogenesis and lipid droplet formation. Deletion of Seipin has been well-demonstrated to cause severe general lipodystrophy, however, its role in maintaining perivascular adipose tissue (PVAT) and vascular homeostasis has not been directly...

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Bibliographic Details
Main Authors: Mengyu Wang, Junhui Xing, Mengduan Liu, Mingming Gao, Yangyang Liu, Xiaowei Li, Liang Hu, Xiaoyan Zhao, Jiawei Liao, George Liu, Jianzeng Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Seipin
lipodystrophy
PVAT
vascular function
anticontractile function
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.706924/full

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