Cancer stem cells: therapeutic implications and perspectives in cancer therapy
The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-04-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383513000208 |
| _version_ | 1819152412626124800 |
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| author | Lu Han Sanjun Shi Tao Gong Zhirong Zhang Xun Sun |
| author_facet | Lu Han Sanjun Shi Tao Gong Zhirong Zhang Xun Sun |
| author_sort | Lu Han |
| collection | DOAJ |
| description | The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and identification of CSCs, the cancer diagnosis, and the cancer therapy. Standard oncology treatments, such as chemotherapy, radiotherapy and surgical resection, can only shrink the bulk tumor and the tumor tends to relapse. Thus, therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffectiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance. The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure. |
| first_indexed | 2024-12-22T14:48:53Z |
| format | Article |
| id | doaj.art-860f43cfde7e4db18e7b7187dd585dbb |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-22T14:48:53Z |
| publishDate | 2013-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-860f43cfde7e4db18e7b7187dd585dbb2022-12-21T18:22:22ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432013-04-0132657510.1016/j.apsb.2013.02.006Cancer stem cells: therapeutic implications and perspectives in cancer therapyLu HanSanjun ShiTao GongZhirong ZhangXun SunThe cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and identification of CSCs, the cancer diagnosis, and the cancer therapy. Standard oncology treatments, such as chemotherapy, radiotherapy and surgical resection, can only shrink the bulk tumor and the tumor tends to relapse. Thus, therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffectiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance. The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure.http://www.sciencedirect.com/science/article/pii/S2211383513000208Cancer stem cellsCancer therapyCSC markerCSC-targeted mechanismResistanceHedgehogNotchWntCSC nicheQuiescent statemiRNA expressionApoptosisDifferentiation |
| spellingShingle | Lu Han Sanjun Shi Tao Gong Zhirong Zhang Xun Sun Cancer stem cells: therapeutic implications and perspectives in cancer therapy Acta Pharmaceutica Sinica B Cancer stem cells Cancer therapy CSC marker CSC-targeted mechanism Resistance Hedgehog Notch Wnt CSC niche Quiescent state miRNA expression Apoptosis Differentiation |
| title | Cancer stem cells: therapeutic implications and perspectives in cancer therapy |
| title_full | Cancer stem cells: therapeutic implications and perspectives in cancer therapy |
| title_fullStr | Cancer stem cells: therapeutic implications and perspectives in cancer therapy |
| title_full_unstemmed | Cancer stem cells: therapeutic implications and perspectives in cancer therapy |
| title_short | Cancer stem cells: therapeutic implications and perspectives in cancer therapy |
| title_sort | cancer stem cells therapeutic implications and perspectives in cancer therapy |
| topic | Cancer stem cells Cancer therapy CSC marker CSC-targeted mechanism Resistance Hedgehog Notch Wnt CSC niche Quiescent state miRNA expression Apoptosis Differentiation |
| url | http://www.sciencedirect.com/science/article/pii/S2211383513000208 |
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