Arrhythmia susceptibility in senescent rat hearts
Cardiovascular disease increases with age as well as alterations of cardiac electrophysiological properties, but a detailed knowledge about changes in cardiac electrophysiology relevant to arrhythmogenesis in the elderly is relatively lacking. The aim of this study was to determine specific age-rela...
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-01-01
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| Series: | Journal of Biological Research |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/2143 |
| _version_ | 1818932433425268736 |
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| author | Stefano Rossi Silvana Baruffi Domenico Corradi Sergio Callegari Ezio Musso Andrea Sgoifo Luca Carnevali Michele Miragoli Emilio Macchi |
| author_facet | Stefano Rossi Silvana Baruffi Domenico Corradi Sergio Callegari Ezio Musso Andrea Sgoifo Luca Carnevali Michele Miragoli Emilio Macchi |
| author_sort | Stefano Rossi |
| collection | DOAJ |
| description | Cardiovascular disease increases with age as well as alterations of cardiac electrophysiological properties, but a detailed knowledge about changes in cardiac electrophysiology relevant to arrhythmogenesis in the elderly is relatively lacking. The aim of this study was to determine specific age-related changes in electrophysiological properties of the ventricles which can be related to a structural-functional arrhythmogenic substrate. Multiple epicardial electrograms were recorded on the ventricular surface of in vivo control and aged rats, while arrhythmia vulnerability was investigated by premature stimulation protocols. Single or multiple ectopic beats and sustained ventricular arrhythmias were frequently induced in aged but not in control hearts. Abnormal ventricular activation patterns during sinus rhythm and unchanged conduction velocity during point stimulation in aged hearts suggest the occurrence of impaired impulse conduction through the distal Purkinje system that might create a potential reentry substrate. |
| first_indexed | 2024-12-20T04:32:25Z |
| format | Article |
| id | doaj.art-8611fa07b6074fdfb30215150daca6a6 |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-12-20T04:32:25Z |
| publishDate | 2014-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-8611fa07b6074fdfb30215150daca6a62022-12-21T19:53:21ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302014-01-0187110.4081/jbr.2014.21431436Arrhythmia susceptibility in senescent rat heartsStefano Rossi0Silvana Baruffi1Domenico Corradi2Sergio Callegari3Ezio Musso4Andrea Sgoifo5Luca Carnevali6Michele Miragoli7Emilio Macchi8Department of Biosciences, University of ParmaDepartment of Biosciences, University of ParmaDepartment of Biomedical, Biotechnological and Translational Sciences, University of ParmaDepartment of Cardiology, Vaio Hospital, FidenzaDepartment of Biosciences, University of ParmaDepartment of Neurosciences, University of ParmaDepartment of Neurosciences, University of ParmaCenter of Excellence of Toxicological Research, University of ParmaCenter of Excellence of Toxicological Research, University of ParmaCardiovascular disease increases with age as well as alterations of cardiac electrophysiological properties, but a detailed knowledge about changes in cardiac electrophysiology relevant to arrhythmogenesis in the elderly is relatively lacking. The aim of this study was to determine specific age-related changes in electrophysiological properties of the ventricles which can be related to a structural-functional arrhythmogenic substrate. Multiple epicardial electrograms were recorded on the ventricular surface of in vivo control and aged rats, while arrhythmia vulnerability was investigated by premature stimulation protocols. Single or multiple ectopic beats and sustained ventricular arrhythmias were frequently induced in aged but not in control hearts. Abnormal ventricular activation patterns during sinus rhythm and unchanged conduction velocity during point stimulation in aged hearts suggest the occurrence of impaired impulse conduction through the distal Purkinje system that might create a potential reentry substrate.http://www.pagepressjournals.org/index.php/jbr/article/view/2143aged heart, arrhythmia, epicardial mapping |
| spellingShingle | Stefano Rossi Silvana Baruffi Domenico Corradi Sergio Callegari Ezio Musso Andrea Sgoifo Luca Carnevali Michele Miragoli Emilio Macchi Arrhythmia susceptibility in senescent rat hearts Journal of Biological Research aged heart, arrhythmia, epicardial mapping |
| title | Arrhythmia susceptibility in senescent rat hearts |
| title_full | Arrhythmia susceptibility in senescent rat hearts |
| title_fullStr | Arrhythmia susceptibility in senescent rat hearts |
| title_full_unstemmed | Arrhythmia susceptibility in senescent rat hearts |
| title_short | Arrhythmia susceptibility in senescent rat hearts |
| title_sort | arrhythmia susceptibility in senescent rat hearts |
| topic | aged heart, arrhythmia, epicardial mapping |
| url | http://www.pagepressjournals.org/index.php/jbr/article/view/2143 |
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