Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes
IntroductionThe role of gut microbiome dysbiosis in the pathogenesis of psoriasis has gained increasing attention in recent years. Secukinumab, targeting interleukin (IL)-17, has a promising efficacy in psoriasis treatment. However, it remains unclear the gut microbiota alteration and related functi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1227309/full |
| _version_ | 1797749038534098944 |
|---|---|
| author | Xueshan Du Cong Yan Shuzhen Kong Delu Che Delu Che Bin Peng Longfei Zhu Songmei Geng Songmei Geng Kun Guo |
| author_facet | Xueshan Du Cong Yan Shuzhen Kong Delu Che Delu Che Bin Peng Longfei Zhu Songmei Geng Songmei Geng Kun Guo |
| author_sort | Xueshan Du |
| collection | DOAJ |
| description | IntroductionThe role of gut microbiome dysbiosis in the pathogenesis of psoriasis has gained increasing attention in recent years. Secukinumab, targeting interleukin (IL)-17, has a promising efficacy in psoriasis treatment. However, it remains unclear the gut microbiota alteration and related functional changes caused by successful secukinumab therapy in psoriatic patients.MethodsIn our study, we compared the fecal microbiome profile between psoriatic patients after secukinumab successful treatment (AT) and the other two groups, psoriatic patients without therapy (BT) and healthy people (H), respectively, by using next-generation sequencing targeting 16S ribosomal RNA. Then, shotgun metagenomic sequencing was first used to characterize bacterial gut microbial communities and related functional changes in the AT group.ResultsWe found that the diversity and structure of the microbial community in the AT group were significantly changed compared to those in the BT group and the H group. The AT group showed a microbiota profile characterized by increased proportions of the phylum Firmicute, families Ruminococcaceae, and a reduction in the phylum Bacteroidota (elevated F/B ratio). To detect functional alteration, we discovered that secukinumab treatment may construct a more stable homeostasis of the gut microbiome with functional alteration. There were different KEGG pathways, such as the downregulated cardiovascular diseases pathway and the upregulated infectious diseases in the AT group. By metagenomic analysis, the metabolic functional pathway was changed after secukinumab therapy.DiscussionIt seems that gut microbiota investigation during biologic drug treatment is useful for predicting the efficacy and risks of drug treatment in disease. |
| first_indexed | 2024-03-12T16:13:33Z |
| format | Article |
| id | doaj.art-86122df025d94617a0ecab1378aeda26 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-12T16:13:33Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-86122df025d94617a0ecab1378aeda262023-08-09T08:27:16ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-08-011410.3389/fmicb.2023.12273091227309Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changesXueshan Du0Cong Yan1Shuzhen Kong2Delu Che3Delu Che4Bin Peng5Longfei Zhu6Songmei Geng7Songmei Geng8Kun Guo9Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaCenter for Dermatology Disease, Precision Medical Institute, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaCenter for Dermatology Disease, Precision Medical Institute, Xi'an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaIntroductionThe role of gut microbiome dysbiosis in the pathogenesis of psoriasis has gained increasing attention in recent years. Secukinumab, targeting interleukin (IL)-17, has a promising efficacy in psoriasis treatment. However, it remains unclear the gut microbiota alteration and related functional changes caused by successful secukinumab therapy in psoriatic patients.MethodsIn our study, we compared the fecal microbiome profile between psoriatic patients after secukinumab successful treatment (AT) and the other two groups, psoriatic patients without therapy (BT) and healthy people (H), respectively, by using next-generation sequencing targeting 16S ribosomal RNA. Then, shotgun metagenomic sequencing was first used to characterize bacterial gut microbial communities and related functional changes in the AT group.ResultsWe found that the diversity and structure of the microbial community in the AT group were significantly changed compared to those in the BT group and the H group. The AT group showed a microbiota profile characterized by increased proportions of the phylum Firmicute, families Ruminococcaceae, and a reduction in the phylum Bacteroidota (elevated F/B ratio). To detect functional alteration, we discovered that secukinumab treatment may construct a more stable homeostasis of the gut microbiome with functional alteration. There were different KEGG pathways, such as the downregulated cardiovascular diseases pathway and the upregulated infectious diseases in the AT group. By metagenomic analysis, the metabolic functional pathway was changed after secukinumab therapy.DiscussionIt seems that gut microbiota investigation during biologic drug treatment is useful for predicting the efficacy and risks of drug treatment in disease.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1227309/fullsecukinumabgut microbiotapsoriasis16S rRNA gene sequencingshotgun metagenomic analysis |
| spellingShingle | Xueshan Du Cong Yan Shuzhen Kong Delu Che Delu Che Bin Peng Longfei Zhu Songmei Geng Songmei Geng Kun Guo Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes Frontiers in Microbiology secukinumab gut microbiota psoriasis 16S rRNA gene sequencing shotgun metagenomic analysis |
| title | Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes |
| title_full | Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes |
| title_fullStr | Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes |
| title_full_unstemmed | Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes |
| title_short | Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes |
| title_sort | successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes |
| topic | secukinumab gut microbiota psoriasis 16S rRNA gene sequencing shotgun metagenomic analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1227309/full |
| work_keys_str_mv | AT xueshandu successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT congyan successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT shuzhenkong successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT deluche successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT deluche successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT binpeng successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT longfeizhu successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT songmeigeng successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT songmeigeng successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges AT kunguo successfulsecukinumabtherapyinplaquepsoriasisisassociatedwithalteredgutmicrobiotaandrelatedfunctionalchanges |