MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
Maitane Umerez,1 Ángela Gutierrez-Camino,1 Carmen Muñoz-Maldonado,1 Idoia Martin-Guerrero,1 Africa Garcia-Orad1,2 1Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursery, University of the Basque Country, UPV/EHU, Leioa, 2BioCruces...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-03-01
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| Series: | Pharmacogenomics and Personalized Medicine |
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| Online Access: | https://www.dovepress.com/mthfr-polymorphisms-in-childhood-acute-lymphoblastic-leukemia-influenc-peer-reviewed-article-PGPM |
| _version_ | 1818048562995396608 |
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| author | Umerez M Gutierrez-Camino Á Muñoz-Maldonado C Martin-Guerrero I Garcia-Orad A |
| author_facet | Umerez M Gutierrez-Camino Á Muñoz-Maldonado C Martin-Guerrero I Garcia-Orad A |
| author_sort | Umerez M |
| collection | DOAJ |
| description | Maitane Umerez,1 Ángela Gutierrez-Camino,1 Carmen Muñoz-Maldonado,1 Idoia Martin-Guerrero,1 Africa Garcia-Orad1,2 1Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursery, University of the Basque Country, UPV/EHU, Leioa, 2BioCruces Health Research Institute, Barakaldo, Spain Abstract: Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this review, we show that the majority of published reports do not find association or present opposite effect. Therefore, MTHFR C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. The efforts should be focused on other genes, such as transporter genes or microRNA-related genes. Keywords: MTHFR, methotrexate, toxicity, outcome, C677T, A1298C |
| first_indexed | 2024-12-10T10:23:40Z |
| format | Article |
| id | doaj.art-861355382664428fa34b14dc2a293c92 |
| institution | Directory Open Access Journal |
| issn | 1178-7066 |
| language | English |
| last_indexed | 2024-12-10T10:23:40Z |
| publishDate | 2017-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Pharmacogenomics and Personalized Medicine |
| spelling | doaj.art-861355382664428fa34b14dc2a293c922022-12-22T01:52:48ZengDove Medical PressPharmacogenomics and Personalized Medicine1178-70662017-03-01Volume10697832077MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapyUmerez MGutierrez-Camino ÁMuñoz-Maldonado CMartin-Guerrero IGarcia-Orad AMaitane Umerez,1 Ángela Gutierrez-Camino,1 Carmen Muñoz-Maldonado,1 Idoia Martin-Guerrero,1 Africa Garcia-Orad1,2 1Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursery, University of the Basque Country, UPV/EHU, Leioa, 2BioCruces Health Research Institute, Barakaldo, Spain Abstract: Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this review, we show that the majority of published reports do not find association or present opposite effect. Therefore, MTHFR C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. The efforts should be focused on other genes, such as transporter genes or microRNA-related genes. Keywords: MTHFR, methotrexate, toxicity, outcome, C677T, A1298Chttps://www.dovepress.com/mthfr-polymorphisms-in-childhood-acute-lymphoblastic-leukemia-influenc-peer-reviewed-article-PGPMMTHFRmethotrexatetoxicityoutcomeC677TA1298C |
| spellingShingle | Umerez M Gutierrez-Camino Á Muñoz-Maldonado C Martin-Guerrero I Garcia-Orad A MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy Pharmacogenomics and Personalized Medicine MTHFR methotrexate toxicity outcome C677T A1298C |
| title | MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy |
| title_full | MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy |
| title_fullStr | MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy |
| title_full_unstemmed | MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy |
| title_short | MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy |
| title_sort | mthfr polymorphisms in childhood acute lymphoblastic leukemia influence on methotrexate therapy |
| topic | MTHFR methotrexate toxicity outcome C677T A1298C |
| url | https://www.dovepress.com/mthfr-polymorphisms-in-childhood-acute-lymphoblastic-leukemia-influenc-peer-reviewed-article-PGPM |
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