Case Report: Multiple Myeloma with Gangrene of Extremities
Introduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia and hypercalcemia. The hyper viscosity syndrome is rare. Cryoglobulins are immunoglubulins that...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2009-07-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://85.185.157.11:6280/jssu/browse.php?a_id=327&slc_lang=en&sid=1&ftxt=1 |
| _version_ | 1818642054590234624 |
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| author | N Gharahi MB Owlia H Soleimani M Akhavan M Karimi MR Mortazavizade |
| author_facet | N Gharahi MB Owlia H Soleimani M Akhavan M Karimi MR Mortazavizade |
| author_sort | N Gharahi |
| collection | DOAJ |
| description | Introduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia and hypercalcemia. The hyper viscosity syndrome is rare. Cryoglobulins are immunoglubulins that precipitate at temperatures less than 37degrees Celsius. Monoclonal cryoglobulins are usually present along with a specific hematologic disorder and are often asymptomatic. We report a second case of multiple myeloma with gangrene of all four extremities. Case: The Patient was a 77 year–old farmer with a 2 weeks history of coldness, pain and discoloration of the fingers of both the extremities which had extended to the mid forearm and shin regions. It was accompanied by skin erosions of the lower extremities, dark spots on the ear auricles and discoloration of the tip of the nose. On physical examination, quadrigangrene associated with ischemia of the auricles and tip of nose was seen. Serum proteins electrophoresis demonstrated monoclonal gammopathy and serum was positive for cryoglobulin, Bone marrow study showed neoplastic plasma cells infiltration. The patient was diagnosed as cryoglobulinemia based on multiple myeloma and treated accordingly. |
| first_indexed | 2024-12-16T23:36:58Z |
| format | Article |
| id | doaj.art-8614e79fcc6a4131bb781e063ac776de |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-12-16T23:36:58Z |
| publishDate | 2009-07-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-8614e79fcc6a4131bb781e063ac776de2022-12-21T22:11:43ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332009-07-01173193196Case Report: Multiple Myeloma with Gangrene of ExtremitiesN GharahiMB OwliaH SoleimaniM AkhavanM KarimiMR MortazavizadeIntroduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia and hypercalcemia. The hyper viscosity syndrome is rare. Cryoglobulins are immunoglubulins that precipitate at temperatures less than 37degrees Celsius. Monoclonal cryoglobulins are usually present along with a specific hematologic disorder and are often asymptomatic. We report a second case of multiple myeloma with gangrene of all four extremities. Case: The Patient was a 77 year–old farmer with a 2 weeks history of coldness, pain and discoloration of the fingers of both the extremities which had extended to the mid forearm and shin regions. It was accompanied by skin erosions of the lower extremities, dark spots on the ear auricles and discoloration of the tip of the nose. On physical examination, quadrigangrene associated with ischemia of the auricles and tip of nose was seen. Serum proteins electrophoresis demonstrated monoclonal gammopathy and serum was positive for cryoglobulin, Bone marrow study showed neoplastic plasma cells infiltration. The patient was diagnosed as cryoglobulinemia based on multiple myeloma and treated accordingly.http://85.185.157.11:6280/jssu/browse.php?a_id=327&slc_lang=en&sid=1&ftxt=1Multiple myelomaCryoglobulinemiaGangrene |
| spellingShingle | N Gharahi MB Owlia H Soleimani M Akhavan M Karimi MR Mortazavizade Case Report: Multiple Myeloma with Gangrene of Extremities Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Multiple myeloma Cryoglobulinemia Gangrene |
| title | Case Report: Multiple Myeloma with Gangrene of Extremities |
| title_full | Case Report: Multiple Myeloma with Gangrene of Extremities |
| title_fullStr | Case Report: Multiple Myeloma with Gangrene of Extremities |
| title_full_unstemmed | Case Report: Multiple Myeloma with Gangrene of Extremities |
| title_short | Case Report: Multiple Myeloma with Gangrene of Extremities |
| title_sort | case report multiple myeloma with gangrene of extremities |
| topic | Multiple myeloma Cryoglobulinemia Gangrene |
| url | http://85.185.157.11:6280/jssu/browse.php?a_id=327&slc_lang=en&sid=1&ftxt=1 |
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