Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review
IntroductionThyroid hormones exert multiple physiological effects essential to the maintenance of basal metabolic rate (BMR), adaptive thermogenesis, fat metabolism, growth, and appetite. The links between obesity and the hormones of the thyroid axis, i.e., triiodothyronine (T3), thyroxine (T4), and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1040167/full |
| _version_ | 1797953960820080640 |
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| author | Carlos Ramos Urrea Amanda Paula Pedroso Fernanda Thomazini Andreia Cristina Feitosa do Carmo Mônica Marques Telles Ana Lydia Sawaya Maria do Carmo Pinho Franco Eliane Beraldi Ribeiro |
| author_facet | Carlos Ramos Urrea Amanda Paula Pedroso Fernanda Thomazini Andreia Cristina Feitosa do Carmo Mônica Marques Telles Ana Lydia Sawaya Maria do Carmo Pinho Franco Eliane Beraldi Ribeiro |
| author_sort | Carlos Ramos Urrea |
| collection | DOAJ |
| description | IntroductionThyroid hormones exert multiple physiological effects essential to the maintenance of basal metabolic rate (BMR), adaptive thermogenesis, fat metabolism, growth, and appetite. The links between obesity and the hormones of the thyroid axis, i.e., triiodothyronine (T3), thyroxine (T4), and thyrotropin (TSH), are still controversial, especially when considering children and adolescents. This population has high rates of overweight and obesity and several treatment approaches, including nutritional, psychological, and physical exercise interventions have been used. Understanding the importance of the hormones of the thyroid axis in the recovery from overweight and obesity may help directing measures to the maintenance of a healthy body composition. The present scoping review was carried out to analyze studies evaluating these hormonal levels throughout interventions directed at treating overweight and obesity in children and adolescents. The main purpose was to ascertain whether the hormones levels vary during weight loss.MethodsWe selected for analysis 19 studies published between 1999 and 2022.ResultsMost of the studies showed that changes in different anthropometric indicators, in response to the multidisciplinary interventions, correlated positively with free T3 (fT3), total T3 (TT3), and TSH. With respect to free T4 (fT4) and total T4 (TT4).DiscussionThe most common finding was of unchanged levels and, hence, no significant association with weight loss. Moreover, thyroxine supplementation has failed to affect the response to the interventions. Further studies are necessary to elucidate the relevance of the variations in hormone levels to the establishment of overweight/obesity and to the recovery from these conditions in children/adolescents.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42020203359. |
| first_indexed | 2024-04-10T23:11:16Z |
| format | Article |
| id | doaj.art-8615e9d6dbfd4810af950ca7b2976119 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T23:11:16Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-8615e9d6dbfd4810af950ca7b29761192023-01-13T05:49:43ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10401671040167Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping reviewCarlos Ramos Urrea0Amanda Paula Pedroso1Fernanda Thomazini2Andreia Cristina Feitosa do Carmo3Mônica Marques Telles4Ana Lydia Sawaya5Maria do Carmo Pinho Franco6Eliane Beraldi Ribeiro7Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilEscola Paulista de Medicina, Campus São Paulo Library, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilIntroductionThyroid hormones exert multiple physiological effects essential to the maintenance of basal metabolic rate (BMR), adaptive thermogenesis, fat metabolism, growth, and appetite. The links between obesity and the hormones of the thyroid axis, i.e., triiodothyronine (T3), thyroxine (T4), and thyrotropin (TSH), are still controversial, especially when considering children and adolescents. This population has high rates of overweight and obesity and several treatment approaches, including nutritional, psychological, and physical exercise interventions have been used. Understanding the importance of the hormones of the thyroid axis in the recovery from overweight and obesity may help directing measures to the maintenance of a healthy body composition. The present scoping review was carried out to analyze studies evaluating these hormonal levels throughout interventions directed at treating overweight and obesity in children and adolescents. The main purpose was to ascertain whether the hormones levels vary during weight loss.MethodsWe selected for analysis 19 studies published between 1999 and 2022.ResultsMost of the studies showed that changes in different anthropometric indicators, in response to the multidisciplinary interventions, correlated positively with free T3 (fT3), total T3 (TT3), and TSH. With respect to free T4 (fT4) and total T4 (TT4).DiscussionThe most common finding was of unchanged levels and, hence, no significant association with weight loss. Moreover, thyroxine supplementation has failed to affect the response to the interventions. Further studies are necessary to elucidate the relevance of the variations in hormone levels to the establishment of overweight/obesity and to the recovery from these conditions in children/adolescents.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42020203359.https://www.frontiersin.org/articles/10.3389/fnut.2022.1040167/fullthyroid hormonesmultidisciplinary interventionobesitychildrenadolescentrecovery |
| spellingShingle | Carlos Ramos Urrea Amanda Paula Pedroso Fernanda Thomazini Andreia Cristina Feitosa do Carmo Mônica Marques Telles Ana Lydia Sawaya Maria do Carmo Pinho Franco Eliane Beraldi Ribeiro Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review Frontiers in Nutrition thyroid hormones multidisciplinary intervention obesity children adolescent recovery |
| title | Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review |
| title_full | Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review |
| title_fullStr | Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review |
| title_full_unstemmed | Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review |
| title_short | Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review |
| title_sort | thyroid axis hormones and anthropometric recovery of children adolescents with overweight obesity a scoping review |
| topic | thyroid hormones multidisciplinary intervention obesity children adolescent recovery |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1040167/full |
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