Vascular Health of Females with History of Assisted Reproductive Technology
The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/11/2/66 |
| _version_ | 1797297876680835072 |
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| author | Pengzhu Li Magdalena Langer Theresa Vilsmaier Marie Kramer Franziska Sciuk Brenda Kolbinger André Jakob Nina Rogenhofer Robert Dalla-Pozza Christian Thaler Nikolaus Alexander Haas Felix Sebastian Oberhoffer |
| author_facet | Pengzhu Li Magdalena Langer Theresa Vilsmaier Marie Kramer Franziska Sciuk Brenda Kolbinger André Jakob Nina Rogenhofer Robert Dalla-Pozza Christian Thaler Nikolaus Alexander Haas Felix Sebastian Oberhoffer |
| author_sort | Pengzhu Li |
| collection | DOAJ |
| description | The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compared to individuals who conceived spontaneously. The assessment of overall vascular health included the measurement of brachial blood pressure, central blood pressure, and pulse wave velocity, as well as the evaluation of the arterial stiffness and carotid intima-media thickness (cIMT) of the common carotid arteries. Conventional blood lipids including lipoprotein a (Lp(a)) were also determined. In total, 45 females with history of ART and 52 females who conceived spontaneously were included (mean age: 47.72 ± 5.96 years vs. 46.84 ± 7.43 years, <i>p</i> = 0.525). An initial comparison revealed a significantly higher prevalence of elevated Lp(a) in ART females (<i>p</i> = 0.011). However, after multiple comparison correction, the significant result disappeared (<i>p</i> = 0.132). Within the cohort of ART females, no significantly higher cardiovascular risk was detected regarding vascular function. The potentially higher prevalence of elevated Lp(a) in ART females must be further investigated in future studies, as it might contribute to the impaired reproductive process in this cohort. |
| first_indexed | 2024-03-07T22:27:44Z |
| format | Article |
| id | doaj.art-861663c899594c5480389e4335fd88af |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-07T22:27:44Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-861663c899594c5480389e4335fd88af2024-02-23T15:21:46ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252024-02-011126610.3390/jcdd11020066Vascular Health of Females with History of Assisted Reproductive TechnologyPengzhu Li0Magdalena Langer1Theresa Vilsmaier2Marie Kramer3Franziska Sciuk4Brenda Kolbinger5André Jakob6Nina Rogenhofer7Robert Dalla-Pozza8Christian Thaler9Nikolaus Alexander Haas10Felix Sebastian Oberhoffer11Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, GermanyThe use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compared to individuals who conceived spontaneously. The assessment of overall vascular health included the measurement of brachial blood pressure, central blood pressure, and pulse wave velocity, as well as the evaluation of the arterial stiffness and carotid intima-media thickness (cIMT) of the common carotid arteries. Conventional blood lipids including lipoprotein a (Lp(a)) were also determined. In total, 45 females with history of ART and 52 females who conceived spontaneously were included (mean age: 47.72 ± 5.96 years vs. 46.84 ± 7.43 years, <i>p</i> = 0.525). An initial comparison revealed a significantly higher prevalence of elevated Lp(a) in ART females (<i>p</i> = 0.011). However, after multiple comparison correction, the significant result disappeared (<i>p</i> = 0.132). Within the cohort of ART females, no significantly higher cardiovascular risk was detected regarding vascular function. The potentially higher prevalence of elevated Lp(a) in ART females must be further investigated in future studies, as it might contribute to the impaired reproductive process in this cohort.https://www.mdpi.com/2308-3425/11/2/66infertilityassisted reproductive technologiesfemalesvascular health |
| spellingShingle | Pengzhu Li Magdalena Langer Theresa Vilsmaier Marie Kramer Franziska Sciuk Brenda Kolbinger André Jakob Nina Rogenhofer Robert Dalla-Pozza Christian Thaler Nikolaus Alexander Haas Felix Sebastian Oberhoffer Vascular Health of Females with History of Assisted Reproductive Technology Journal of Cardiovascular Development and Disease infertility assisted reproductive technologies females vascular health |
| title | Vascular Health of Females with History of Assisted Reproductive Technology |
| title_full | Vascular Health of Females with History of Assisted Reproductive Technology |
| title_fullStr | Vascular Health of Females with History of Assisted Reproductive Technology |
| title_full_unstemmed | Vascular Health of Females with History of Assisted Reproductive Technology |
| title_short | Vascular Health of Females with History of Assisted Reproductive Technology |
| title_sort | vascular health of females with history of assisted reproductive technology |
| topic | infertility assisted reproductive technologies females vascular health |
| url | https://www.mdpi.com/2308-3425/11/2/66 |
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