Plasma apolipoprotein O level increased in the patients with acute coronary syndrome
Apolipoprotein (apo) O is a novel apolipoprotein that is present predominantly in high density lipoprotein (HDL). However, overexpression of apoO does not impact on plasma HDL levels or functionality in human apoA-I transgenic mice. Thus, the physiological function of apoO is not yet known. In the p...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-09-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520418371 |
| _version_ | 1818732520701689856 |
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| author | Bi-lian Yu Chen-lu Wu Shui-ping Zhao |
| author_facet | Bi-lian Yu Chen-lu Wu Shui-ping Zhao |
| author_sort | Bi-lian Yu |
| collection | DOAJ |
| description | Apolipoprotein (apo) O is a novel apolipoprotein that is present predominantly in high density lipoprotein (HDL). However, overexpression of apoO does not impact on plasma HDL levels or functionality in human apoA-I transgenic mice. Thus, the physiological function of apoO is not yet known. In the present study, we investigated relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects (n = 111) and patients with established acute coronary syndrome (ACS) (n = 50). ApoO was measured by the sandwich dot-blot technique with recombinant apoO as a protein standard. Mean apoO level in healthy subjects was 2.21 ± 0.83 µg/ml whereas it was 4.94 ± 1.59 µg/ml in ACS patients. There were significant differences in plasma level of apoO between two groups (P < 0.001). In univariate analysis, apoO correlated significantly with lg(hsCRP) (r = 0.48, P < 0.001) in ACS patients. Notably, no significant correlation between apoO and other lipid parameters was observed. Logistic regression analysis showed that plasma apoO level was an independent predictor of ACS (OR = 5.61, 95% CI 2.16–14.60, P < 0.001). In conclusion, apoO increased in ACS patients, and may be regarded as an independent inflammatory predictor of ACS patients. |
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| format | Article |
| id | doaj.art-8616d4e80a104caba3404aa87913f0e0 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T23:34:53Z |
| publishDate | 2012-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-8616d4e80a104caba3404aa87913f0e02022-12-21T21:28:35ZengElsevierJournal of Lipid Research0022-22752012-09-0153919521957Plasma apolipoprotein O level increased in the patients with acute coronary syndromeBi-lian Yu0Chen-lu Wu1Shui-ping Zhao2Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR ChinaDepartment of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR ChinaTo whom correspondence should be addressed. e-mail: zhaosp@medmail.com.cn.; To whom correspondence should be addressed. e-mail: zhaosp@medmail.com.cn.; Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR ChinaApolipoprotein (apo) O is a novel apolipoprotein that is present predominantly in high density lipoprotein (HDL). However, overexpression of apoO does not impact on plasma HDL levels or functionality in human apoA-I transgenic mice. Thus, the physiological function of apoO is not yet known. In the present study, we investigated relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects (n = 111) and patients with established acute coronary syndrome (ACS) (n = 50). ApoO was measured by the sandwich dot-blot technique with recombinant apoO as a protein standard. Mean apoO level in healthy subjects was 2.21 ± 0.83 µg/ml whereas it was 4.94 ± 1.59 µg/ml in ACS patients. There were significant differences in plasma level of apoO between two groups (P < 0.001). In univariate analysis, apoO correlated significantly with lg(hsCRP) (r = 0.48, P < 0.001) in ACS patients. Notably, no significant correlation between apoO and other lipid parameters was observed. Logistic regression analysis showed that plasma apoO level was an independent predictor of ACS (OR = 5.61, 95% CI 2.16–14.60, P < 0.001). In conclusion, apoO increased in ACS patients, and may be regarded as an independent inflammatory predictor of ACS patients.http://www.sciencedirect.com/science/article/pii/S0022227520418371apolipoproteinsatherosclerosishigh density lipoproteininflammationlipoproteins |
| spellingShingle | Bi-lian Yu Chen-lu Wu Shui-ping Zhao Plasma apolipoprotein O level increased in the patients with acute coronary syndrome Journal of Lipid Research apolipoproteins atherosclerosis high density lipoprotein inflammation lipoproteins |
| title | Plasma apolipoprotein O level increased in the patients with acute coronary syndrome |
| title_full | Plasma apolipoprotein O level increased in the patients with acute coronary syndrome |
| title_fullStr | Plasma apolipoprotein O level increased in the patients with acute coronary syndrome |
| title_full_unstemmed | Plasma apolipoprotein O level increased in the patients with acute coronary syndrome |
| title_short | Plasma apolipoprotein O level increased in the patients with acute coronary syndrome |
| title_sort | plasma apolipoprotein o level increased in the patients with acute coronary syndrome |
| topic | apolipoproteins atherosclerosis high density lipoprotein inflammation lipoproteins |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520418371 |
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