The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the rec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/2030 |
| _version_ | 1797524315903623168 |
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| author | Yabing Liang Ling Yang Jingwu Xie |
| author_facet | Yabing Liang Ling Yang Jingwu Xie |
| author_sort | Yabing Liang |
| collection | DOAJ |
| description | The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway’s roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling. |
| first_indexed | 2024-03-10T08:55:37Z |
| format | Article |
| id | doaj.art-8617d484d6214947ba2fa40478ec4901 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:55:37Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8617d484d6214947ba2fa40478ec49012023-11-22T07:10:44ZengMDPI AGCells2073-44092021-08-01108203010.3390/cells10082030The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal CancersYabing Liang0Ling Yang1Jingwu Xie2Inner Mongolia Key Laboratory of Medical Cell Biology, Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, ChinaInner Mongolia Key Laboratory of Medical Cell Biology, Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, ChinaWells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USAThe hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway’s roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.https://www.mdpi.com/2073-4409/10/8/2030the hedgehog pathwaychemotherapyresistancegastric cancercolorectal cancerpancreatic cancer |
| spellingShingle | Yabing Liang Ling Yang Jingwu Xie The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers Cells the hedgehog pathway chemotherapy resistance gastric cancer colorectal cancer pancreatic cancer |
| title | The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers |
| title_full | The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers |
| title_fullStr | The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers |
| title_full_unstemmed | The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers |
| title_short | The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers |
| title_sort | role of the hedgehog pathway in chemoresistance of gastrointestinal cancers |
| topic | the hedgehog pathway chemotherapy resistance gastric cancer colorectal cancer pancreatic cancer |
| url | https://www.mdpi.com/2073-4409/10/8/2030 |
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