KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration
Abstract KDELR2 has been reported as a promotive factor for the genesis and progression of several malignancies. However, it is uncertain how it affects bladder urothelial carcinoma (BLCA). Using data extracted from online databases, an enhanced expression of KDELR2 in BLCA tissues was verified. Ove...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2023-09-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000500103&lng=en&tlng=en |
| _version_ | 1827807121741185024 |
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| author | Sai Ma Longqi Sa Jitao Zhang Kuo Jiang Baoguo Mi Lequn Shan |
| author_facet | Sai Ma Longqi Sa Jitao Zhang Kuo Jiang Baoguo Mi Lequn Shan |
| author_sort | Sai Ma |
| collection | DOAJ |
| description | Abstract KDELR2 has been reported as a promotive factor for the genesis and progression of several malignancies. However, it is uncertain how it affects bladder urothelial carcinoma (BLCA). Using data extracted from online databases, an enhanced expression of KDELR2 in BLCA tissues was verified. Overexpression of KDELR2 was correlated with advanced clinicopathologic characteristics and unfavourable prognosis of BLCA. Receiver operating characteristic analysis highlighted the potential diagnostic value of KDELR2. Univariate and multivariate logistic regression analyses further revealed the predictive effect of KDELR2 for the prognosis of BLCA. KDELR2 was primarily enriched in biological functions related to organization of the extracellular matrix. TIMER, ssGSEA and GEPIA analyses suggested that KDELR2 expression is positively related to the infiltration of macrophages, Th2 cells and neutrophils. Finally, knocking-down of KDELR2 in T24 cells resulted in reduced proliferation, migration and macrophages recruitment. These results suggest that KDELR2 overexpression is an indicator for poor prognosis of BLCA and it has the potential to be employed as an immunotherapy target for BLCA. |
| first_indexed | 2024-03-11T21:52:42Z |
| format | Article |
| id | doaj.art-8619deb797d34af8b0740fe755459e18 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-03-11T21:52:42Z |
| publishDate | 2023-09-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-8619deb797d34af8b0740fe755459e182023-09-26T07:43:56ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852023-09-0146310.1590/1678-4685-gmb-2023-0002KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltrationSai MaLongqi SaJitao ZhangKuo JiangBaoguo MiLequn Shanhttps://orcid.org/0000-0001-7015-5436Abstract KDELR2 has been reported as a promotive factor for the genesis and progression of several malignancies. However, it is uncertain how it affects bladder urothelial carcinoma (BLCA). Using data extracted from online databases, an enhanced expression of KDELR2 in BLCA tissues was verified. Overexpression of KDELR2 was correlated with advanced clinicopathologic characteristics and unfavourable prognosis of BLCA. Receiver operating characteristic analysis highlighted the potential diagnostic value of KDELR2. Univariate and multivariate logistic regression analyses further revealed the predictive effect of KDELR2 for the prognosis of BLCA. KDELR2 was primarily enriched in biological functions related to organization of the extracellular matrix. TIMER, ssGSEA and GEPIA analyses suggested that KDELR2 expression is positively related to the infiltration of macrophages, Th2 cells and neutrophils. Finally, knocking-down of KDELR2 in T24 cells resulted in reduced proliferation, migration and macrophages recruitment. These results suggest that KDELR2 overexpression is an indicator for poor prognosis of BLCA and it has the potential to be employed as an immunotherapy target for BLCA.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000500103&lng=en&tlng=enBladder Urothelial Carcinoma (BLCA)Bioinformatic analysisImmune infiltrationKDELR2 |
| spellingShingle | Sai Ma Longqi Sa Jitao Zhang Kuo Jiang Baoguo Mi Lequn Shan KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration Genetics and Molecular Biology Bladder Urothelial Carcinoma (BLCA) Bioinformatic analysis Immune infiltration KDELR2 |
| title | KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration |
| title_full | KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration |
| title_fullStr | KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration |
| title_full_unstemmed | KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration |
| title_short | KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration |
| title_sort | kdelr2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration |
| topic | Bladder Urothelial Carcinoma (BLCA) Bioinformatic analysis Immune infiltration KDELR2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000500103&lng=en&tlng=en |
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