Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis
ObjectiveThe aim of this study is to evaluate the effectiveness and safety of curcumin in rheumatoid arthritis patients.MethodsA computerized search from PubMed, Embase, Cochrane Library, and Web of Science databases was performed until 3 March 2023. Literature screening, basic data extraction and r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121655/full |
| _version_ | 1797815510946021376 |
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| author | Haiyang Kou Lei Huang Meng Jin Qi He Rui Zhang Rui Zhang Jianbing Ma |
| author_facet | Haiyang Kou Lei Huang Meng Jin Qi He Rui Zhang Rui Zhang Jianbing Ma |
| author_sort | Haiyang Kou |
| collection | DOAJ |
| description | ObjectiveThe aim of this study is to evaluate the effectiveness and safety of curcumin in rheumatoid arthritis patients.MethodsA computerized search from PubMed, Embase, Cochrane Library, and Web of Science databases was performed until 3 March 2023. Literature screening, basic data extraction and risk of bias evaluation were independently performed by two researchers each. The quality evaluation of the literature was performed according to the Cochrane Handbook for Risk of Bias Assessment tool for treatment evaluation.ResultsThe current study includes six publications covering 539 rheumatoid arthritis patients. The activity of rheumatoid arthritis was assessed using erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), protein, disease activity score (DAS), rheumatoid factor (RF), Visual Analogue Scale (VAS) pain, tender joint count (TJC) and swollen joint count (SJC). ESR (MD = -29.47, 95% CI [-54.05, -4.88], Z=2.35, P = 0.02), DAS28 (MD = -1.20, 95% CI [-1.85, -0.55], Z=3.62, P = 0.0003), SJC (MD = -5.33, 95% CI [-9.90, -0.76], Z = 2.29, P = 0.02) and TJC (MD = -6.33, 95% CI [-10.86, -1.81], Z = 2.74, P = 0.006) showed significantly change in experimental patients compared with controls.ConclusionCurcumin is beneficial for rheumatoid arthritis treatment. Inflammation levels and clinical symptoms in patients with rheumatoid arthritis can be improved by curcumin supplementation. Large sample randomized controlled trials on the effects of curcumin on patients with rheumatoid arthritis are needed in the future.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022361992). |
| first_indexed | 2024-03-13T08:23:54Z |
| format | Article |
| id | doaj.art-8619e9d760a648efa61b884fe47b6ac1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T08:23:54Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8619e9d760a648efa61b884fe47b6ac12023-05-31T04:55:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11216551121655Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysisHaiyang Kou0Lei Huang1Meng Jin2Qi He3Rui Zhang4Rui Zhang5Jianbing Ma6Department of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medical Technology, Guiyang Healthcare Vocational University, Guiyang, Guizhou, ChinaDepartment of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaObjectiveThe aim of this study is to evaluate the effectiveness and safety of curcumin in rheumatoid arthritis patients.MethodsA computerized search from PubMed, Embase, Cochrane Library, and Web of Science databases was performed until 3 March 2023. Literature screening, basic data extraction and risk of bias evaluation were independently performed by two researchers each. The quality evaluation of the literature was performed according to the Cochrane Handbook for Risk of Bias Assessment tool for treatment evaluation.ResultsThe current study includes six publications covering 539 rheumatoid arthritis patients. The activity of rheumatoid arthritis was assessed using erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), protein, disease activity score (DAS), rheumatoid factor (RF), Visual Analogue Scale (VAS) pain, tender joint count (TJC) and swollen joint count (SJC). ESR (MD = -29.47, 95% CI [-54.05, -4.88], Z=2.35, P = 0.02), DAS28 (MD = -1.20, 95% CI [-1.85, -0.55], Z=3.62, P = 0.0003), SJC (MD = -5.33, 95% CI [-9.90, -0.76], Z = 2.29, P = 0.02) and TJC (MD = -6.33, 95% CI [-10.86, -1.81], Z = 2.74, P = 0.006) showed significantly change in experimental patients compared with controls.ConclusionCurcumin is beneficial for rheumatoid arthritis treatment. Inflammation levels and clinical symptoms in patients with rheumatoid arthritis can be improved by curcumin supplementation. Large sample randomized controlled trials on the effects of curcumin on patients with rheumatoid arthritis are needed in the future.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022361992).https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121655/fullcurcuminrheumatoid arthritisarthritisinflammatoryantioxidants |
| spellingShingle | Haiyang Kou Lei Huang Meng Jin Qi He Rui Zhang Rui Zhang Jianbing Ma Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis Frontiers in Immunology curcumin rheumatoid arthritis arthritis inflammatory antioxidants |
| title | Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis |
| title_full | Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis |
| title_fullStr | Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis |
| title_short | Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis |
| title_sort | effect of curcumin on rheumatoid arthritis a systematic review and meta analysis |
| topic | curcumin rheumatoid arthritis arthritis inflammatory antioxidants |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121655/full |
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