Polar Interactions at the Dimer–Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization

Polar Interactions at the Dimer–Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization

Catalytic MATα1 subunits associate into kinetically distinct homo-dimers (MAT III) and homo-tetramers (MAT I) that synthesize S-adenosylmethionine in the adult liver. Pathological reductions in S-adenosylmethionine levels correlate with MAT III accumulation; thus, it is important to know the determi...

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Bibliographic Details
Main Authors: Gabino Francisco Sánchez-Pérez, María Ángeles Pajares
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
association mechanism
cooperativity
dimer/tetramer ratio
methionine cycle
oligomerization
polar interactions
Online Access:https://www.mdpi.com/1422-0067/22/24/13206

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