Colorectal Cancer Pulmonary Metastasectomy: When, Why and How
Colorectal cancer is the third-most-diagnosed cancer in males and in females, representing 8% of estimated new cases, and the third cause of cancer-related death in both sexes, accounting for 9% of cancer deaths in men and 8% in women. About 20% of patients diagnosed with CRC present metastatic dise...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/7/1408 |
| _version_ | 1797212785447272448 |
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| author | Francesco Petrella Federica Danuzzo Maria Chiara Sibilia Sara Vaquer Raffaella Longarini Alessandro Guidi Federico Raveglia Lidia Libretti Emanuele Pirondini Andrea Cara Enrico Mario Cassina Antonio Tuoro Diego Cortinovis |
| author_facet | Francesco Petrella Federica Danuzzo Maria Chiara Sibilia Sara Vaquer Raffaella Longarini Alessandro Guidi Federico Raveglia Lidia Libretti Emanuele Pirondini Andrea Cara Enrico Mario Cassina Antonio Tuoro Diego Cortinovis |
| author_sort | Francesco Petrella |
| collection | DOAJ |
| description | Colorectal cancer is the third-most-diagnosed cancer in males and in females, representing 8% of estimated new cases, and the third cause of cancer-related death in both sexes, accounting for 9% of cancer deaths in men and 8% in women. About 20% of patients diagnosed with CRC present metastatic disease. Although lung metachronous or synchronous metastatic spread without other involved sites has been reported in only a small proportion of patients, considering that this tumor is frequently diagnosed, the clinical approach to CRC pulmonary metastases represents a major issue for thoracic surgeons and CRC oncologists. Among patients diagnosed with pulmonary metastases from CRC, about 9–12% are eligible for local treatments with radical intent, including surgical resection, SBRT (stereotactic body radiation therapy) and ablation therapy. Due to the lack of randomized controlled trials among different local strategies, there is no definitive evidence about the optimal approach, although surgical resection is considered the most effective therapeutic option in this clinical scenario. Oncological achievement of primary radical resection, the biology of primary tumor and metastatic sites, disease free interval and or progression free survival are independent prognostic factors which make it possible to define a cohort of patients which might significantly benefit from pulmonary metastasectomy. |
| first_indexed | 2024-04-24T10:47:54Z |
| format | Article |
| id | doaj.art-861a2ab76c584bc3b64873b3813c1b60 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-04-24T10:47:54Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-861a2ab76c584bc3b64873b3813c1b602024-04-12T13:16:16ZengMDPI AGCancers2072-66942024-04-01167140810.3390/cancers16071408Colorectal Cancer Pulmonary Metastasectomy: When, Why and HowFrancesco Petrella0Federica Danuzzo1Maria Chiara Sibilia2Sara Vaquer3Raffaella Longarini4Alessandro Guidi5Federico Raveglia6Lidia Libretti7Emanuele Pirondini8Andrea Cara9Enrico Mario Cassina10Antonio Tuoro11Diego Cortinovis12Division of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyDivision of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, 20900 Monza, ItalyColorectal cancer is the third-most-diagnosed cancer in males and in females, representing 8% of estimated new cases, and the third cause of cancer-related death in both sexes, accounting for 9% of cancer deaths in men and 8% in women. About 20% of patients diagnosed with CRC present metastatic disease. Although lung metachronous or synchronous metastatic spread without other involved sites has been reported in only a small proportion of patients, considering that this tumor is frequently diagnosed, the clinical approach to CRC pulmonary metastases represents a major issue for thoracic surgeons and CRC oncologists. Among patients diagnosed with pulmonary metastases from CRC, about 9–12% are eligible for local treatments with radical intent, including surgical resection, SBRT (stereotactic body radiation therapy) and ablation therapy. Due to the lack of randomized controlled trials among different local strategies, there is no definitive evidence about the optimal approach, although surgical resection is considered the most effective therapeutic option in this clinical scenario. Oncological achievement of primary radical resection, the biology of primary tumor and metastatic sites, disease free interval and or progression free survival are independent prognostic factors which make it possible to define a cohort of patients which might significantly benefit from pulmonary metastasectomy.https://www.mdpi.com/2072-6694/16/7/1408colorectal cancerpulmonary metastasectomydisease free intervaloverall survival |
| spellingShingle | Francesco Petrella Federica Danuzzo Maria Chiara Sibilia Sara Vaquer Raffaella Longarini Alessandro Guidi Federico Raveglia Lidia Libretti Emanuele Pirondini Andrea Cara Enrico Mario Cassina Antonio Tuoro Diego Cortinovis Colorectal Cancer Pulmonary Metastasectomy: When, Why and How Cancers colorectal cancer pulmonary metastasectomy disease free interval overall survival |
| title | Colorectal Cancer Pulmonary Metastasectomy: When, Why and How |
| title_full | Colorectal Cancer Pulmonary Metastasectomy: When, Why and How |
| title_fullStr | Colorectal Cancer Pulmonary Metastasectomy: When, Why and How |
| title_full_unstemmed | Colorectal Cancer Pulmonary Metastasectomy: When, Why and How |
| title_short | Colorectal Cancer Pulmonary Metastasectomy: When, Why and How |
| title_sort | colorectal cancer pulmonary metastasectomy when why and how |
| topic | colorectal cancer pulmonary metastasectomy disease free interval overall survival |
| url | https://www.mdpi.com/2072-6694/16/7/1408 |
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