Solid-Phase Synthesis of Oligodeoxynucleotides Containing N4-[2-(t-butyldisulfanyl)ethyl]-5-methylcytosine Moieties

Solid-Phase Synthesis of Oligodeoxynucleotides Containing N4-[2-(t-butyldisulfanyl)ethyl]-5-methylcytosine Moieties

An efficient route for the synthesis of the phosphoramidite derivative of 5-methylcytosine bearing a tert-butylsulfanyl group protected thiol is described. This building block is used for the preparation of oligonucleotides carrying a thiol group at the nucleobase at the internal position of a DNA s...

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Bibliographic Details
Main Authors: Sónia Pérez-Rentero, Ramón Eritja, Alejandra V. Garibotti
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Molecules
Subjects:
solid-phase synthesis
oligonucleotides
DNA
thiol
oligonucleotide conjugates
Online Access:http://www.mdpi.com/1420-3049/15/8/5692/

Internet

http://www.mdpi.com/1420-3049/15/8/5692/

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