Targeting Raf Kinase Inhibitory Protein Regulation and Function
Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals mol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/10/9/306 |
| _version_ | 1797766526327062528 |
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| author | Ali Ekrem Yesilkanal Marsha Rich Rosner |
| author_facet | Ali Ekrem Yesilkanal Marsha Rich Rosner |
| author_sort | Ali Ekrem Yesilkanal |
| collection | DOAJ |
| description | Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis. |
| first_indexed | 2024-03-12T20:26:28Z |
| format | Article |
| id | doaj.art-861bbe97f13f4cf5a0dec3f48d790d95 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:26:28Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-861bbe97f13f4cf5a0dec3f48d790d952023-08-02T00:28:20ZengMDPI AGCancers2072-66942018-09-0110930610.3390/cancers10090306cancers10090306Targeting Raf Kinase Inhibitory Protein Regulation and FunctionAli Ekrem Yesilkanal0Marsha Rich Rosner1Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USABen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USARaf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis.http://www.mdpi.com/2072-6694/10/9/306RKIPmetastasissuppressorkinasetherapysignaling |
| spellingShingle | Ali Ekrem Yesilkanal Marsha Rich Rosner Targeting Raf Kinase Inhibitory Protein Regulation and Function Cancers RKIP metastasis suppressor kinase therapy signaling |
| title | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
| title_full | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
| title_fullStr | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
| title_full_unstemmed | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
| title_short | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
| title_sort | targeting raf kinase inhibitory protein regulation and function |
| topic | RKIP metastasis suppressor kinase therapy signaling |
| url | http://www.mdpi.com/2072-6694/10/9/306 |
| work_keys_str_mv | AT aliekremyesilkanal targetingrafkinaseinhibitoryproteinregulationandfunction AT marsharichrosner targetingrafkinaseinhibitoryproteinregulationandfunction |