Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis
<p>Abstract</p> <p>Background</p> <p>In this report the phytochemical profile of <it>Nitraria. Retusa (N. Retusa</it>) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.<...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-10-01
|
| Series: | Cancer Cell International |
| Online Access: | http://www.cancerci.com/content/11/1/37 |
| _version_ | 1818568892335783936 |
|---|---|
| author | Bouhlel Ines Sghaier Mohamed Bhouri Wissem Boubaker Jihed Skandrani Ines Ghedira Kamel Chekir-Ghedira Leila |
| author_facet | Bouhlel Ines Sghaier Mohamed Bhouri Wissem Boubaker Jihed Skandrani Ines Ghedira Kamel Chekir-Ghedira Leila |
| author_sort | Bouhlel Ines |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In this report the phytochemical profile of <it>Nitraria. Retusa (N. Retusa</it>) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.</p> <p>Methods</p> <p>Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investigating DNA fragmentation, PARP cleavage and caspases 3 and 8 inducing activities, in the presence of <it>N. retusa </it>extracts.</p> <p>Results</p> <p>Our study revealed that the tested extracts from <it>N. Retusa </it>contain many useful bioactive compounds. They induced in a time-dependent manner the apoptosis the tested cancerous our cell line. This result was confirmed by ladder DNA fragmentation profile and PARP cleavage, as well as a release in caspase-3 and caspase-8 level.</p> <p>Conclusion</p> <p>Our results indicate that the tested compounds have a significant antiproliferative effect which may be due to their involvement in the induction of the extrinsic apoptosic pathway.</p> |
| first_indexed | 2024-12-14T06:41:01Z |
| format | Article |
| id | doaj.art-861d242c875a40368529991b7476a705 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-14T06:41:01Z |
| publishDate | 2011-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-861d242c875a40368529991b7476a7052022-12-21T23:13:13ZengBMCCancer Cell International1475-28672011-10-011113710.1186/1475-2867-11-37Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosisBouhlel InesSghaier MohamedBhouri WissemBoubaker JihedSkandrani InesGhedira KamelChekir-Ghedira Leila<p>Abstract</p> <p>Background</p> <p>In this report the phytochemical profile of <it>Nitraria. Retusa (N. Retusa</it>) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.</p> <p>Methods</p> <p>Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investigating DNA fragmentation, PARP cleavage and caspases 3 and 8 inducing activities, in the presence of <it>N. retusa </it>extracts.</p> <p>Results</p> <p>Our study revealed that the tested extracts from <it>N. Retusa </it>contain many useful bioactive compounds. They induced in a time-dependent manner the apoptosis the tested cancerous our cell line. This result was confirmed by ladder DNA fragmentation profile and PARP cleavage, as well as a release in caspase-3 and caspase-8 level.</p> <p>Conclusion</p> <p>Our results indicate that the tested compounds have a significant antiproliferative effect which may be due to their involvement in the induction of the extrinsic apoptosic pathway.</p>http://www.cancerci.com/content/11/1/37 |
| spellingShingle | Bouhlel Ines Sghaier Mohamed Bhouri Wissem Boubaker Jihed Skandrani Ines Ghedira Kamel Chekir-Ghedira Leila Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis Cancer Cell International |
| title | Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis |
| title_full | Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis |
| title_fullStr | Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis |
| title_full_unstemmed | Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis |
| title_short | Leaf extracts from <it>Nitraria retusa </it>promote cell population growth of human cancer cells by inducing apoptosis |
| title_sort | leaf extracts from it nitraria retusa it promote cell population growth of human cancer cells by inducing apoptosis |
| url | http://www.cancerci.com/content/11/1/37 |
| work_keys_str_mv | AT bouhlelines leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis AT sghaiermohamed leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis AT bhouriwissem leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis AT boubakerjihed leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis AT skandraniines leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis AT ghedirakamel leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis AT chekirghediraleila leafextractsfromitnitrariaretusaitpromotecellpopulationgrowthofhumancancercellsbyinducingapoptosis |