A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility
Abstract Observational studies have provided evidence of a correlation between alterations in gut microbiota composition and infertility. However, concrete proof supporting the causal relationship is still lacking. We performed a Mendelian randomization study to assess whether genetically gut microb...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38624-6 |
| _version_ | 1797778912007159808 |
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| author | Taozhi Li Wenbo Shao Yukun Wang Rui Zhou Zhangjun Yun Yalin He Yu Wu |
| author_facet | Taozhi Li Wenbo Shao Yukun Wang Rui Zhou Zhangjun Yun Yalin He Yu Wu |
| author_sort | Taozhi Li |
| collection | DOAJ |
| description | Abstract Observational studies have provided evidence of a correlation between alterations in gut microbiota composition and infertility. However, concrete proof supporting the causal relationship is still lacking. We performed a Mendelian randomization study to assess whether genetically gut microbiota composition influences the risk of infertility. The genetic data pertaining to gut microbiota were obtained from a genome-wide association study meta-analysis, which was conducted among 24 cohorts (18,340 participants) from the international MiBioGen consortium. By the primary method of assessing causality, we have identified 2 family taxa, 2 genus taxa, and 1 order taxa that were linked to a low risk of male infertility, while 1 genus taxa were associated with a high risk of male infertility. Furthermore, we have discovered 6 genus taxa, 1 phylum taxa, 1 class taxa, 1 order taxa, and 1 family taxa that were associated with a low risk of female infertility, while 1 genus taxa were linked to a high risk of female infertility. This study successfully confirmed that there was a causal link between gut microbiota and infertility. The identification of these specific strains through genetic prediction offers a valuable insight for early diagnosis, prevention, and treatment of infertility. |
| first_indexed | 2024-03-12T23:24:22Z |
| format | Article |
| id | doaj.art-861dddaab25f47efaca24b630625a6b5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T23:24:22Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-861dddaab25f47efaca24b630625a6b52023-07-16T11:14:39ZengNature PortfolioScientific Reports2045-23222023-07-011311810.1038/s41598-023-38624-6A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertilityTaozhi Li0Wenbo Shao1Yukun Wang2Rui Zhou3Zhangjun Yun4Yalin He5Yu Wu6Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical SciencesDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing University of Chinese MedicineDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical SciencesBeijing University of Chinese MedicineChongqing Jiangjin District Hospital of Traditional Chinese MedicineDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical SciencesAbstract Observational studies have provided evidence of a correlation between alterations in gut microbiota composition and infertility. However, concrete proof supporting the causal relationship is still lacking. We performed a Mendelian randomization study to assess whether genetically gut microbiota composition influences the risk of infertility. The genetic data pertaining to gut microbiota were obtained from a genome-wide association study meta-analysis, which was conducted among 24 cohorts (18,340 participants) from the international MiBioGen consortium. By the primary method of assessing causality, we have identified 2 family taxa, 2 genus taxa, and 1 order taxa that were linked to a low risk of male infertility, while 1 genus taxa were associated with a high risk of male infertility. Furthermore, we have discovered 6 genus taxa, 1 phylum taxa, 1 class taxa, 1 order taxa, and 1 family taxa that were associated with a low risk of female infertility, while 1 genus taxa were linked to a high risk of female infertility. This study successfully confirmed that there was a causal link between gut microbiota and infertility. The identification of these specific strains through genetic prediction offers a valuable insight for early diagnosis, prevention, and treatment of infertility.https://doi.org/10.1038/s41598-023-38624-6 |
| spellingShingle | Taozhi Li Wenbo Shao Yukun Wang Rui Zhou Zhangjun Yun Yalin He Yu Wu A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility Scientific Reports |
| title | A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility |
| title_full | A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility |
| title_fullStr | A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility |
| title_full_unstemmed | A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility |
| title_short | A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility |
| title_sort | two sample mendelian randomization analysis investigates associations between gut microbiota and infertility |
| url | https://doi.org/10.1038/s41598-023-38624-6 |
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