INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants
Abstract Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the D...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-021-00384-7 |
| _version_ | 1797642719274729472 |
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| author | Viviane M. Andrade Aaron Christensen-Quick Joseph Agnes Jared Tur Charles Reed Richa Kalia Idania Marrero Dustin Elwood Katherine Schultheis Mansi Purwar Emma Reuschel Trevor McMullan Patrick Pezzoli Kim Kraynyak Albert Sylvester Mammen P. Mammen Pablo Tebas J. Joseph Kim David B. Weiner Trevor R. F. Smith Stephanie J. Ramos Laurent M. Humeau Jean D. Boyer Kate E. Broderick |
| author_facet | Viviane M. Andrade Aaron Christensen-Quick Joseph Agnes Jared Tur Charles Reed Richa Kalia Idania Marrero Dustin Elwood Katherine Schultheis Mansi Purwar Emma Reuschel Trevor McMullan Patrick Pezzoli Kim Kraynyak Albert Sylvester Mammen P. Mammen Pablo Tebas J. Joseph Kim David B. Weiner Trevor R. F. Smith Stephanie J. Ramos Laurent M. Humeau Jean D. Boyer Kate E. Broderick |
| author_sort | Viviane M. Andrade |
| collection | DOAJ |
| description | Abstract Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested. |
| first_indexed | 2024-03-11T14:04:21Z |
| format | Article |
| id | doaj.art-861f6b3de24f4eca965d9adae892bcdd |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-11T14:04:21Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-861f6b3de24f4eca965d9adae892bcdd2023-11-02T03:01:10ZengNature Portfolionpj Vaccines2059-01052021-10-01611410.1038/s41541-021-00384-7INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variantsViviane M. Andrade0Aaron Christensen-Quick1Joseph Agnes2Jared Tur3Charles Reed4Richa Kalia5Idania Marrero6Dustin Elwood7Katherine Schultheis8Mansi Purwar9Emma Reuschel10Trevor McMullan11Patrick Pezzoli12Kim Kraynyak13Albert Sylvester14Mammen P. Mammen15Pablo Tebas16J. Joseph Kim17David B. Weiner18Trevor R. F. Smith19Stephanie J. Ramos20Laurent M. Humeau21Jean D. Boyer22Kate E. Broderick23Inovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsVaccine and Immunotherapy Center, Wistar InstituteVaccine and Immunotherapy Center, Wistar InstituteInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsHospital of the University of PennsylvaniaInovio PharmaceuticalsVaccine and Immunotherapy Center, Wistar InstituteInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsInovio PharmaceuticalsAbstract Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.https://doi.org/10.1038/s41541-021-00384-7 |
| spellingShingle | Viviane M. Andrade Aaron Christensen-Quick Joseph Agnes Jared Tur Charles Reed Richa Kalia Idania Marrero Dustin Elwood Katherine Schultheis Mansi Purwar Emma Reuschel Trevor McMullan Patrick Pezzoli Kim Kraynyak Albert Sylvester Mammen P. Mammen Pablo Tebas J. Joseph Kim David B. Weiner Trevor R. F. Smith Stephanie J. Ramos Laurent M. Humeau Jean D. Boyer Kate E. Broderick INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants npj Vaccines |
| title | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_full | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_fullStr | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_full_unstemmed | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_short | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_sort | ino 4800 dna vaccine induces neutralizing antibodies and t cell activity against global sars cov 2 variants |
| url | https://doi.org/10.1038/s41541-021-00384-7 |
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