3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs
It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/7/2/32 |
| _version_ | 1797571819524325376 |
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| author | Hun-Jin Jeong Hyoryung Nam Jinah Jang Seung-Jae Lee |
| author_facet | Hun-Jin Jeong Hyoryung Nam Jinah Jang Seung-Jae Lee |
| author_sort | Hun-Jin Jeong |
| collection | DOAJ |
| description | It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs. |
| first_indexed | 2024-03-10T20:46:58Z |
| format | Article |
| id | doaj.art-862226cc8db34c71a2a08ae9bfc53914 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T20:46:58Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-862226cc8db34c71a2a08ae9bfc539142023-11-19T20:16:54ZengMDPI AGBioengineering2306-53542020-03-01723210.3390/bioengineering70200323D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and OrgansHun-Jin Jeong0Hyoryung Nam1Jinah Jang2Seung-Jae Lee3Department of Mechanical Engineering, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do 54538, KoreaDepartment of Creative IT Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, KoreaDepartment of Creative IT Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, KoreaDepartment of Mechanical Engineering, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do 54538, KoreaIt is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs.https://www.mdpi.com/2306-5354/7/2/323D bioprintingbiocomposite inktubular tissuetubular organ |
| spellingShingle | Hun-Jin Jeong Hyoryung Nam Jinah Jang Seung-Jae Lee 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs Bioengineering 3D bioprinting biocomposite ink tubular tissue tubular organ |
| title | 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs |
| title_full | 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs |
| title_fullStr | 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs |
| title_full_unstemmed | 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs |
| title_short | 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs |
| title_sort | 3d bioprinting strategies for the regeneration of functional tubular tissues and organs |
| topic | 3D bioprinting biocomposite ink tubular tissue tubular organ |
| url | https://www.mdpi.com/2306-5354/7/2/32 |
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