Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia
The evaluation of the biological effects of therapeutic hyperthermia in oncology and the precise quantification of thermal dose, when heating is coupled with radiotherapy or chemotherapy, are active fields of research. The reliable measurement of hyperthermia effects on cells and tissues requires a...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/22/10/3610 |
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| author | Riccardo Ferrero Ioannis Androulakis Luca Martino Robin Nadar Gerard C. van Rhoon Alessandra Manzin |
| author_facet | Riccardo Ferrero Ioannis Androulakis Luca Martino Robin Nadar Gerard C. van Rhoon Alessandra Manzin |
| author_sort | Riccardo Ferrero |
| collection | DOAJ |
| description | The evaluation of the biological effects of therapeutic hyperthermia in oncology and the precise quantification of thermal dose, when heating is coupled with radiotherapy or chemotherapy, are active fields of research. The reliable measurement of hyperthermia effects on cells and tissues requires a strong control of the delivered power and of the induced temperature rise. To this aim, we have developed a radiofrequency (RF) electromagnetic applicator operating at 434 MHz, specifically engineered for in vitro tests on 3D cell cultures. The applicator has been designed with the aid of an extensive modelling analysis, which combines electromagnetic and thermal simulations. The heating performance of the built prototype has been validated by means of temperature measurements carried out on tissue-mimicking phantoms and aimed at monitoring both spatial and temporal temperature variations. The experimental results demonstrate the capability of the RF applicator to produce a well-focused heating, with the possibility of modulating the duration of the heating transient and controlling the temperature rise in a specific target region, by simply tuning the effectively supplied power. |
| first_indexed | 2024-03-10T01:55:05Z |
| format | Article |
| id | doaj.art-8624933a1a9f43d59775b2a755723acf |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T01:55:05Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-8624933a1a9f43d59775b2a755723acf2023-11-23T12:58:10ZengMDPI AGSensors1424-82202022-05-012210361010.3390/s22103610Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic HyperthermiaRiccardo Ferrero0Ioannis Androulakis1Luca Martino2Robin Nadar3Gerard C. van Rhoon4Alessandra Manzin5Istituto Nazionale di Ricerca Metrologica (INRIM), 10135 Torino, ItalyDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015 GD Rotterdam, The NetherlandsIstituto Nazionale di Ricerca Metrologica (INRIM), 10135 Torino, ItalyDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015 GD Rotterdam, The NetherlandsIstituto Nazionale di Ricerca Metrologica (INRIM), 10135 Torino, ItalyThe evaluation of the biological effects of therapeutic hyperthermia in oncology and the precise quantification of thermal dose, when heating is coupled with radiotherapy or chemotherapy, are active fields of research. The reliable measurement of hyperthermia effects on cells and tissues requires a strong control of the delivered power and of the induced temperature rise. To this aim, we have developed a radiofrequency (RF) electromagnetic applicator operating at 434 MHz, specifically engineered for in vitro tests on 3D cell cultures. The applicator has been designed with the aid of an extensive modelling analysis, which combines electromagnetic and thermal simulations. The heating performance of the built prototype has been validated by means of temperature measurements carried out on tissue-mimicking phantoms and aimed at monitoring both spatial and temporal temperature variations. The experimental results demonstrate the capability of the RF applicator to produce a well-focused heating, with the possibility of modulating the duration of the heating transient and controlling the temperature rise in a specific target region, by simply tuning the effectively supplied power.https://www.mdpi.com/1424-8220/22/10/3610thermal therapieselectromagnetic hyperthermiaRF applicatorTEM modecoaxial cableelectromagnetic modelling |
| spellingShingle | Riccardo Ferrero Ioannis Androulakis Luca Martino Robin Nadar Gerard C. van Rhoon Alessandra Manzin Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia Sensors thermal therapies electromagnetic hyperthermia RF applicator TEM mode coaxial cable electromagnetic modelling |
| title | Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia |
| title_full | Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia |
| title_fullStr | Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia |
| title_full_unstemmed | Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia |
| title_short | Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia |
| title_sort | design and characterization of an rf applicator for in vitro tests of electromagnetic hyperthermia |
| topic | thermal therapies electromagnetic hyperthermia RF applicator TEM mode coaxial cable electromagnetic modelling |
| url | https://www.mdpi.com/1424-8220/22/10/3610 |
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