CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/9/1/7 |
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| author | Mohamed M. Ali Imaduddin Mirza Dina Naquiallah Chandra Hassan Mario Masrur Francesco M. Bianco Abeer M. Mahmoud |
| author_facet | Mohamed M. Ali Imaduddin Mirza Dina Naquiallah Chandra Hassan Mario Masrur Francesco M. Bianco Abeer M. Mahmoud |
| author_sort | Mohamed M. Ali |
| collection | DOAJ |
| description | CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic milieu characterized by hyperglycemia and abundant glycation-end-products (AGEs). We examined the circulating and visceral adipose tissue (VAT) levels of CD147 and their correlation with vascular function in obese, obese diabetic, and non-obese controls (<i>n</i> = 40, each). The circulating levels of CD147 and the glycosylated CD147 protein in VAT were considerably higher in obese, particularly obese diabetic subjects compared to controls. Obese diabetics had the lowest brachial and arteriolar vasoreactivity and the highest carotid pulse-wave velocity (PWV, a measure of arterial stiffness) among the three groups. CD147 correlated positively with body mass index (BMI), total and visceral fat mass, PWV, and plasma levels of glucose, insulin, MMPs, and AGEs and negatively with brachial artery and VAT-arteriolar vasoreactivity and nitric oxide production. Multivariate regression revealed that BMI, body fat mass, insulin, and glucose levels significantly predicted CD147. Our data suggest that higher levels of CD147 in obese subjects, particularly those with diabetes, are linked to vascular dysfunction and several cardiometabolic risk factors. |
| first_indexed | 2024-03-10T01:15:18Z |
| format | Article |
| id | doaj.art-8626139dac25447f87973b672ca2b866 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T01:15:18Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-8626139dac25447f87973b672ca2b8662023-11-23T14:10:59ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-12-0191710.3390/jcdd9010007CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic AdultsMohamed M. Ali0Imaduddin Mirza1Dina Naquiallah2Chandra Hassan3Mario Masrur4Francesco M. Bianco5Abeer M. Mahmoud6Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USACD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic milieu characterized by hyperglycemia and abundant glycation-end-products (AGEs). We examined the circulating and visceral adipose tissue (VAT) levels of CD147 and their correlation with vascular function in obese, obese diabetic, and non-obese controls (<i>n</i> = 40, each). The circulating levels of CD147 and the glycosylated CD147 protein in VAT were considerably higher in obese, particularly obese diabetic subjects compared to controls. Obese diabetics had the lowest brachial and arteriolar vasoreactivity and the highest carotid pulse-wave velocity (PWV, a measure of arterial stiffness) among the three groups. CD147 correlated positively with body mass index (BMI), total and visceral fat mass, PWV, and plasma levels of glucose, insulin, MMPs, and AGEs and negatively with brachial artery and VAT-arteriolar vasoreactivity and nitric oxide production. Multivariate regression revealed that BMI, body fat mass, insulin, and glucose levels significantly predicted CD147. Our data suggest that higher levels of CD147 in obese subjects, particularly those with diabetes, are linked to vascular dysfunction and several cardiometabolic risk factors.https://www.mdpi.com/2308-3425/9/1/7obesitydiabetesvascular dysfunctionCD147matrix metalloproteinasesglycosylation |
| spellingShingle | Mohamed M. Ali Imaduddin Mirza Dina Naquiallah Chandra Hassan Mario Masrur Francesco M. Bianco Abeer M. Mahmoud CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Journal of Cardiovascular Development and Disease obesity diabetes vascular dysfunction CD147 matrix metalloproteinases glycosylation |
| title | CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults |
| title_full | CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults |
| title_fullStr | CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults |
| title_full_unstemmed | CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults |
| title_short | CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults |
| title_sort | cd147 levels in blood and adipose tissues correlate with vascular dysfunction in obese diabetic adults |
| topic | obesity diabetes vascular dysfunction CD147 matrix metalloproteinases glycosylation |
| url | https://www.mdpi.com/2308-3425/9/1/7 |
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