Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway

Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway

Abstract Background Aging disturbs the skin morphology and function, manifested as thinned epithelium and impaired wound healing. As a major type of skin cells, epidermal stem cells (EpiSCs) are inevitably affected by aging. The effect of age on EpiSCs and wound healing needs to be further explored....

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Bibliographic Details
Main Authors: Jiachen Sun, Hongqing Zhao, Chuan’an Shen, Shiyi Li, Wen Zhang, Jinglong Ma, Zhisheng Li, Ming Zhang, Jianqiu Yang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Stem Cell Research & Therapy
Subjects:
Aging
Epidermal growth factor receptor (EGFR)
Tideglusib
Apoptosis
Proliferation
Wound healing
Online Access:https://doi.org/10.1186/s13287-022-02949-2

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