Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22
The main pathogenic factor in atopic dermatitis (AD) is Th2 inflammation, and levels of serum CCL17 and CCL22 are related to severity in AD patients. Fulvic acid (FA) is a kind of natural humic acid with anti-inflammatory, antibacterial, and immunomodulatory effects. Our experiments demonstrated the...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3507 |
| _version_ | 1797604104708554752 |
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| author | Chenxi Wu Anqi Lyu Shijun Shan |
| author_facet | Chenxi Wu Anqi Lyu Shijun Shan |
| author_sort | Chenxi Wu |
| collection | DOAJ |
| description | The main pathogenic factor in atopic dermatitis (AD) is Th2 inflammation, and levels of serum CCL17 and CCL22 are related to severity in AD patients. Fulvic acid (FA) is a kind of natural humic acid with anti-inflammatory, antibacterial, and immunomodulatory effects. Our experiments demonstrated the therapeutic effect of FA on AD mice and revealed some potential mechanisms. FA was shown to reduce TARC/CCL17 and MDC/CCL22 expression in HaCaT cells stimulated by TNF-α and IFN-γ. The inhibitors showed that FA inhibits CCL17 and CCL22 production by deactivating the p38 MAPK and JNK pathways. After 2,4-dinitrochlorobenzene (DNCB) induction in mice with atopic dermatitis, FA effectively reduced the symptoms and serum levels of CCL17 and CCL22. In conclusion, topical FA attenuated AD via downregulation of CCL17 and CCL22, via inhibition of P38 MAPK and JNK phosphorylation, and FA is a potential therapeutic agent for AD. |
| first_indexed | 2024-03-11T04:41:36Z |
| format | Article |
| id | doaj.art-862d3e6c8faf4160b57cba36184442d1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:36Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-862d3e6c8faf4160b57cba36184442d12023-11-17T20:39:57ZengMDPI AGMolecules1420-30492023-04-01288350710.3390/molecules28083507Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22Chenxi Wu0Anqi Lyu1Shijun Shan2Department of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, ChinaDepartment of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, ChinaDepartment of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, ChinaThe main pathogenic factor in atopic dermatitis (AD) is Th2 inflammation, and levels of serum CCL17 and CCL22 are related to severity in AD patients. Fulvic acid (FA) is a kind of natural humic acid with anti-inflammatory, antibacterial, and immunomodulatory effects. Our experiments demonstrated the therapeutic effect of FA on AD mice and revealed some potential mechanisms. FA was shown to reduce TARC/CCL17 and MDC/CCL22 expression in HaCaT cells stimulated by TNF-α and IFN-γ. The inhibitors showed that FA inhibits CCL17 and CCL22 production by deactivating the p38 MAPK and JNK pathways. After 2,4-dinitrochlorobenzene (DNCB) induction in mice with atopic dermatitis, FA effectively reduced the symptoms and serum levels of CCL17 and CCL22. In conclusion, topical FA attenuated AD via downregulation of CCL17 and CCL22, via inhibition of P38 MAPK and JNK phosphorylation, and FA is a potential therapeutic agent for AD.https://www.mdpi.com/1420-3049/28/8/3507atopic dermatitis (AD)fulvic acid (FA)CCL17CCL22 |
| spellingShingle | Chenxi Wu Anqi Lyu Shijun Shan Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22 Molecules atopic dermatitis (AD) fulvic acid (FA) CCL17 CCL22 |
| title | Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22 |
| title_full | Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22 |
| title_fullStr | Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22 |
| title_full_unstemmed | Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22 |
| title_short | Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22 |
| title_sort | fulvic acid attenuates atopic dermatitis by downregulating ccl17 22 |
| topic | atopic dermatitis (AD) fulvic acid (FA) CCL17 CCL22 |
| url | https://www.mdpi.com/1420-3049/28/8/3507 |
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